概要
瘢痕疙瘩是常见病理性皮肤愈合, 极难预防和根治。临床发现黑色素细胞活性较高的深肤色人群具有瘢痕疙瘩易感性, 提示黑色素细胞可能参与其形成过程。瘢痕疙瘩主要由成纤维细胞中TGF-β/Smads通路异常激活所致, 而文献报道黑色素细胞分泌物能激活成纤维细胞中TGF-β信号, 但机制不明。我们前期研究发现携带特定miRNAs的黑色素细胞外泌体可激活成纤维细胞内TGF-β/Smads通路, 从而促进瘢痕疙瘩形成。本研究将从细胞间对话角度揭示深肤色人群易感瘢痕疙瘩的内在机理。
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Acknowledgments
This work is supported by the Zhejiang Provincial Natural Science Foundation of China (No. LQ22H150005) and the National Natural Science Foundation of China (No. 81873937).
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Jiaqi SUN performed the experimental research and data analysis. Zeren SHEN designed the experiments and wrote this article. Jinjin SHAO and Jinghong XU gave some good suggestions on the revision of the manuscript, polished English, and checked the final version. All authors have read and approved the final manuscript, and therefore, have full access to all the data in the study and take responsibility for the integrity and security of the data.
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Zeren SHEN, Jinjin SHAO, Jiaqi SUN, and Jinghong XU declare that they have no conflict of interest.
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study. Additional informed consent was obtained from all patients for whom identifying information is included in this article.
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Shen, Z., Shao, J., Sun, J. et al. Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study. J. Zhejiang Univ. Sci. B 23, 699–704 (2022). https://doi.org/10.1631/jzus.B2200036
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DOI: https://doi.org/10.1631/jzus.B2200036