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Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies

低剂量率脉冲放疗模式显著提高腹部盆腔恶性肿瘤的治疗效果

概要

低剂量率脉冲放射治疗(Pulsed low-dose rate, PLDR)是一种有效且安全的创新性放疗模式. 这种放疗模式可用于肿瘤复发的再程放疗, 同时肿瘤体积大、 无法耐受常规放疗模式的肿瘤患者也能从中获得较好的姑息治疗疗效。在本研究中, 我们首次提出了胰腺癌和前列腺癌的最佳PLDR模型, 研究结果表明个性化的PLDR是一种有效的治疗腹部和盆腔癌的方法.

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Acknowledgments

This work was supported by the Jiangsu Provincial Medical Innovation Team (No. CXTDA2017034), the National Natural Science Foundation of China (No. 81972845), and the Science Foundation of Jiangsu Commission of Health (No. H2018116), China.

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Contributions

Xin WEN performed the experimental research and data analysis, wrote and edited the manuscript. Hui QIU and Zhiying SHAO contributed to the writing and editing of the manuscript. Guihong LIU and Nianli LIU contributed to the study design and experiment guidance. Aoxing CHEN and Xingying ZHANG contributed to the establishment of animal models. Xin DING and Longzhen ZHANG performed the study design, paper guidance, and financial support. All authors have read and approved the final manuscript and, therefore, have full access to all the data in the study and take responsibility for the integrity and security of the data.

Corresponding authors

Correspondence to Xin Ding or Longzhen Zhang.

Ethics declarations

Xin WEN, Hui QIU, Zhiying SHAO, Guihong LIU, Nianli LIU, Aoxing CHEN, Xingying ZHANG, Xin DING, and Longzhen ZHENG declare that they have no conflict of interest.

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Wen, X., Qiu, H., Shao, Z. et al. Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies. J. Zhejiang Univ. Sci. B 22, 774–781 (2021). https://doi.org/10.1631/jzus.B2000793

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关键词

  • 低剂量率脉冲放射治疗
  • 低剂量辐射超敏感性/辐射抗性增强
  • 腹盆腔恶性肿瘤
  • 亚致死损伤半修复时间