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Pharmacokinetic interactions between the potential COVID-19 treatment drugs lopinavir/ritonavir and arbidol in rats

COVID-19潜在治疗药物洛匹那韦/利托那韦和阿比多尔在大鼠体内的药代动力学相互作用

摘要

目的

研究抗病毒药物洛匹那韦/利托那韦和阿比多尔在大鼠体内的药代动力学相互作用.

创新点

洛匹那韦/利托那韦联合阿比多尔作为国内多家医疗单位治疗 COVID-19 患者的基础抗病毒方案, 两者的药物相互作用未有研究报道, 本论文通过开展体内药动学实验, 探索合用后药物体内暴露量的改变, 为该方案的临床治疗有效性和安全性提供保障.

方法

建立大鼠洛匹那韦/利托那韦与阿比多尔药动学相互作用模型. 将大鼠分为3组(阿比多尔组、洛匹那韦/利托那韦组及联用组). 洛匹那韦/利托那韦和阿比多尔分别以50 mg/kg/12.5 mg/kg和25 mg/kg灌胃给药. 采用液相色谱串联质谱 (LC-MS/MS) 法测定洛匹那韦和阿比多尔的浓度.

结论

洛匹那韦/利托那韦联合阿比多尔治疗后, 阿比多尔的药时曲线下面积 (AUC) 和洛匹那韦的峰浓度 (Cmax) 显著升高. 这两种药物的相互作用可能会影响联合治疗的安全性. 因此, 洛匹那韦/利托那韦与阿比多尔同时给药时, 建议适当调整给药剂量, 阿比多尔的剂量可能需要减半.

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Acknowledgments

This work is supported by the National Natural Science Foundation of China (No. 81703612).

Author information

Affiliations

Authors

Corresponding author

Correspondence to Saiping Jiang.

Additional information

Author contributions

Yunzhen HU, Saiping JIANG, and Xiaoyang LU conceived and designed this study. Minjuan ZUO and Xiaojuan WANG carried out the experiments. Yunzhen HU performed data analysis and drafted the manuscript. Rongrong WANG and Lu LI made critical contribution to the discussion. All authors have read and approved the final manuscript and, therefore, have full access to all the data in the study and take responsibility for the integrity and security of the data.

Compliance with ethics guidelines

Yunzhen HU, Minjuan ZUO, Xiaojuan WANG, Rongrong WANG, Lu LI, Xiaoyang LU, and Saiping JIANG declare that they have no conflict of interest.

The Research Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, China) approved the protocol followed in this study. All institutional and national guidelines for the care and use of laboratory animals were followed.

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Hu, Y., Zuo, M., Wang, X. et al. Pharmacokinetic interactions between the potential COVID-19 treatment drugs lopinavir/ritonavir and arbidol in rats. J. Zhejiang Univ. Sci. B 22, 599–602 (2021). https://doi.org/10.1631/jzus.B2000728

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关键词

  • 药代动力学
  • COVID-19
  • 相互作用
  • 洛匹那韦/利托那韦
  • 阿比多尔