Abstract
The role of point-of-care (POC) diagnostics is important in public health. With the support of smartphones, POC diagnostic technologies can be greatly improved. This opportunity has arisen from not only the large number and fast spread of cell-phones across the world but also their improved imaging/diagnostic functions. As a tool, the smartphone is regarded as part of a compact, portable, and low-cost system for real-time POC, even in areas with few resources. By combining near-infrared (NIR) imaging, measurement, and spectroscopy techniques, pathogens can be detected with high sensitivity. The whole process is rapid, accurate, and low-cost, and will set the future trend for POC diagnostics. In this review, the development of smartphone-based NIR fluorescent imaging technology was described, and the quality and potential of POC applications were discussed.
概要
护理点(POC)诊断在公共卫生中起到非常重要的作用。在智能手机的支持下,POC诊断技术得到极大的改进。不仅仅是因为手机在世界范围内的大量使用,而且还得益于其日益增强的成像/拍照功能。智能手机结合近红外成像、测量和光谱技术,可以高灵敏度地检测病原体。整个过程快速、准确、成本低廉,将成为POC诊断的未来趋势。本文综述了基于智能手机的近红外荧光成像技术的发展,并对其应用和潜力进行了讨论。
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This work was supported by the National Natural Science Foundation of China (No. 81773352) and the China Scholarship Council (No. 201703170071).
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Wenjing HUANG did most writing and literature review of the manuscript. Shenglin LUO contributed partial writing and some literature review. Dong YANG edited the manuscript. Sheng ZHANG contributed the framework of the manuscript and supervised the process. All authors have read and approved the final manuscript and, therefore, have full access to all the data in the study and take responsibility for the integrity and security of the data.
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Wenjing HUANG, Shenglin LUO, Dong YANG, and Sheng ZHANG declare that they have no conflict of interest.
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study. Additional informed consent was obtained from all patients for whom identifying information is included in this article.
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Huang, W., Luo, S., Yang, D. et al. Applications of smartphone-based near-infrared (NIR) imaging, measurement, and spectroscopy technologies to point-of-care (POC) diagnostics. J. Zhejiang Univ. Sci. B 22, 171–189 (2021). https://doi.org/10.1631/jzus.B2000388
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DOI: https://doi.org/10.1631/jzus.B2000388
Key words
- Point-of-care (POC) diagnostics
- Near-infrared (NIR) fluorescent imaging
- Aggregation-induced emission (AIE)
- Smartphone-based imaging
- Fluorescent probe