Abstract
Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.
概 要
胸主动脉夹层具有发病急、 发展迅速、 主动脉破裂率高的特点, 是最致命的大动脉疾病之一. 但是胸主动脉夹层的发病机制目前还没有被完全了解. 本综述介绍了三种新兴的β-氨基丙腈相关的小鼠胸主动脉夹层模型, 分别是: 单用β-氨基丙腈; 先用β-氨基丙腈处理 (四周) 再用血管紧张素 2 (AngII) 处理; β-氨基丙腈和 AngII 同时进行处理. 希望通过更好地运用这三种β-氨基丙腈相关的小鼠胸主动脉夹层模型, 从而对胸主动脉夹层的分子机制有更深入的了解.
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The authors thank all Jian-an WANG laboratory members for critical comments on the manuscript.
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Jian-an WANG and Hong S. LU provided the theme and design, and edited the manuscript. Hai-qiong ZHENG participated in searching and summarizing the relevant literature as well as designing and writing the manuscript. Jia-bing RONG, Fei-ming YE, and Yin-chuan XU provided comments and edited the manuscript. All authors have read and approved the final manuscript.
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Hai-qiong ZHENG, Jia-bing RONG, Fei-ming YE, Yin-chuan XU, Hong S. LU, and Jian-an WANG declare that they have no conflicts of interest.
This article does not contain any studies with human or animal subjects performed by any of the authors.
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Project supported by the National Natural Science Foundation of China (Nos. 81870292 and 81971860) and the National Key Research and Development Program of China (No. 2016YFC1301204)
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Zheng, Hq., Rong, Jb., Ye, Fm. et al. Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models. J. Zhejiang Univ. Sci. B 21, 603–610 (2020). https://doi.org/10.1631/jzus.B2000022
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DOI: https://doi.org/10.1631/jzus.B2000022
Key words
- Thoracic aortic dissection (TAD)
- β-Aminopropionitrile (BAPN)
- Angiotensin II (AngII)
- Mouse model
- Hypertension