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Characteristics of chemotherapy-induced diabetes mellitus in acute lymphoblastic leukemia patients

急性淋巴细胞白血病化疗继发糖尿病的临床特点

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概要

目的

明确急性淋巴细胞白血病 (ALL) 患者化疗期间继发糖尿病的发生率, 探索发生继发糖尿病的危险因素及其对患者预后的影响.

创新点

继发糖尿病在 ALL 患者化疗期间常有发生, 但其在不同化疗阶段的发生率、 危险因素及其对患者预后的影响鲜有研究. 本研究以此为切入点, 探索了 ALL 患者化疗继发糖尿病的特点及其对患者预后的影响.

方法

收集浙江大学医学院附属第一医院血液科 2011年 1 月至 2013 年 10 月期间收治的初发 ALL 病例共计 177 例, 筛选出临床资料完整且入院时不合并糖尿病的患者 156 例. 统计患者在诱导化疗期间和全化疗期间继发糖尿病的发生率, 分析糖尿病组与非糖尿病组患者在总生存期、 无事件生存期等方面的差异, 并探讨继发糖尿病的危险因素.

结论

继发糖尿病是 ALL 患者化疗期间重要的并发症, 年龄是化疗期间继发糖尿病的独立预测因子. 对于年龄小于 35 岁的年轻患者, 继发糖尿病患者 相比于正常血糖者其总生存期和无事件生存期 均缩短.

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Acknowledgments

The authors wish to thank all the medical and nursing staff working in the Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, China) for providing outstanding clinical care to our patients.

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Authors and Affiliations

Authors

Contributions

Jie JIN contributed to the conception and design of the study and provided administrative support. Shan-shan SUO, Chen-ying LI, Yi ZHANG, and Wen-juan YU participated in the collection and assembly of data. Shan-shan SUO and Yin-jun LOU performed data analysis and interpretation. Shan-shan SUO and Jing-han WANG were involved in the writing of the manuscript. All authors gave final approval of the manuscript for publication, and have full access to all the data in the study and take responsibility for the integrity and security of the data.

Corresponding author

Correspondence to Jie Jin.

Additional information

Compliance with ethics guidelines

Shan-shan SUO, Chen-ying LI, Yi ZHANG, Jing-han WANG, Yin-jun LOU, Wen-juan YU, and Jie JIN declare that they have no conflict of interest.

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study. The present study was approved by the Ethics Committee of the First Affiliated Hospital of Zhejiang University School of Medicine (Reference Number 2013-277).

Project supported by the Zhejiang Provincial Natural Science Foundation of China (No. LY19H080009)

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Suo, Ss., Li, Cy., Zhang, Y. et al. Characteristics of chemotherapy-induced diabetes mellitus in acute lymphoblastic leukemia patients. J. Zhejiang Univ. Sci. B 21, 740–744 (2020). https://doi.org/10.1631/jzus.B1900719

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  • DOI: https://doi.org/10.1631/jzus.B1900719

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