概要
目的
分析常染色体19 个短串联重复序列(STR)位点 在新疆蒙古族群体中的遗传多态性分布, 为其法 医学应用提供数据支持。
创新点
丰富了新疆蒙古族群体的常染色体STR 遗传数据。
方法
从新疆地区采集1133 个无血缘关系的蒙古族健康 个体, 应用一个包含常染色体19 个STR 位点的 复合扩增体系对这些样本进行基因分型检测。 同 时, 基于15 个共有的STR 位点, 采用多维尺度 分析、遗传距离(DA)和遗传分化系数(FST) 的方法探讨了新疆蒙古族群体和既往报道的20 个群体间的群体遗传关系。
结论
研究的19 个STR 位点在新疆蒙古族群体中表现 出高度的多态性, 获得的累积非父排除概率和累 计个体识别率分别为0.999 999 992 163 和 0.999 999 999 999 999 999 999 995 67, 表明这19 个 STR位点可很好地应用于新疆蒙古族群体的个体 识别和亲缘关系鉴识研究。 群体遗传分析的结果 显示:相比其他洲际群体, 新疆蒙古族群体和维 吾尔族、锡伯族以及其他中国群体具有更近的遗 传距离。
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Project supported by the National Natural Science Foundation of China (No. 81460286) and the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (GDUPS) (2017), China
Electronic supplementary materials: The online version of this article (https://doi.org/10.1631/jzus.B1800279) contains supplementary materials, which are available to authorized users
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Wei, YY., Jin, XY., Lan, Q. et al. Genetic distribution and forensic evaluation of multiplex autosomal short tandem repeats in the Chinese Xinjiang Mongolian group. J. Zhejiang Univ. Sci. B 20, 287–290 (2019). https://doi.org/10.1631/jzus.B1800279
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DOI: https://doi.org/10.1631/jzus.B1800279