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Network analysis identifies common genes associated with obesity in six obesity-related diseases

网络分析筛选六种与肥胖相关疾病的共同的肥胖基因

Journal of Zhejiang University-SCIENCE B volume 18, pages 727–732 (2017)Cite this article

摘要

目 的

通过筛选在六种与肥胖相关疾病中发挥作用的共同的肥胖基因, 阐明肥胖在疾病发生及发展中的作用, 为预防及治疗肥胖相关的一系列疾病提供参考。

创新点

首次分析了与肥胖相关疾病的共同的肥胖基因, 为解释肥胖与疾病的关系提供理论支持。

方 法

从疾病及肥胖数据库中获得与疾病和肥胖相关的基因, 利用生物信息学软件进行蛋白互作网络分析和中心基因分析, 筛选中心基因; 对疾病与肥胖数据库中的重叠基因进行GO(Gene Ontology,基因本体)功能富集, 获得在疾病中发挥作用的共同的基因本体功能集群。

结 论

通过分析初步推测六种与肥胖相关疾病中的31个中心基因中包括17 个肥胖基因, 每种疾病与肥胖的重叠基因具有一些相同的基因本体功能集群。

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Affiliations

  1. Department of Biology, Hebei North University, Zhangjiakou, 075029, China

    Li-ning Su & Hui-ping Wei

  2. Department of Public Sports, Hebei North University, Zhangjiakou, 075029, China

    Yan-bing Wang

  3. Department of Cardiac Function Examination, the First Affiliated Hospital, Hebei North University, Zhangjiakou, 075061, China

    Chun-guang Wnag

Authors
  1. Li-ning Su
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  2. Yan-bing Wang
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  3. Chun-guang Wnag
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  4. Hui-ping Wei
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Corresponding author

Correspondence to Hui-ping Wei.

Additional information

Project supported by the Key Project of Hebei North University (No. 120177) and the Key Project of Medical Science Research in Hebei Province (No. 20150061), China

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Su, Ln., Wang, Yb., Wnag, Cg. et al. Network analysis identifies common genes associated with obesity in six obesity-related diseases. J. Zhejiang Univ. Sci. B 18, 727–732 (2017). https://doi.org/10.1631/jzus.B1600454

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  • DOI: https://doi.org/10.1631/jzus.B1600454

关键词

  • 肥胖
  • 肥胖相关疾病
  • 冠状动脉疾病
  • 高血压
  • 糖尿病
  • 乳腺癌
  • 肾癌
  • 多囊综合症