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Mesenchymal stem cells as therapeutic agents and in gene delivery for the treatment of glioma

间充质干细胞在胶质瘤治疗中的作用研究

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Abstract

Mesenchymal stem cells (MSCs) are plastic-adherent cells with a characteristic surface phenotype and properties of self-renewal, differentiation, and high proliferative potential. The characteristics of MSCs and their tumortropic capability make them an ideal tool for use in cell-based therapies for cancer, including glioma. These cells can function either through a bystander effect or as a delivery system for genes and drugs. MSCs have been demonstrated to inhibit the growth of glioma and to improve survival following transplantation into the brain. We briefly review the current data regarding the use of MSCs in the treatment of glioma and discuss the potential strategies for development of a more specific and effective therapy.

中文概要

胶质瘤是颅内发病率最高的恶性肿瘤,虽然临床 上可以用“手术+化疗”的方法进行治疗,但由 于其浸润性,对化疗药物的低敏感性等原因,常 在治疗后复发,严重威胁人类生命健康。间充质 干细胞(MSC)是干细胞中的一员,具有增殖能 力强、分化潜能大、免疫原性低及采集方便等优 点,其趋化性更使MSC 成为肿瘤治疗的一个理 想工具。本文对干细胞治疗胶质瘤的研究现状进 行了归纳总结,着重阐述了MSC 的旁分泌途径 作用及作为基因载体导入肿瘤坏死因子相关凋 亡诱导配体(TRAIL)、溶瘤病毒等其他治疗基 因的生物功能,以期对进一步的治疗研究提供帮 助。

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Acknowledgments

This work is supported by State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.

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Authors and Affiliations

  1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China

    Bing-yu Xiang, Lu Chen, Xiao-jun Wang & Charlie Xiang

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  1. Bing-yu Xiang
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  2. Lu Chen
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  3. Xiao-jun Wang
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  4. Charlie Xiang
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Correspondence to Charlie Xiang.

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Project supported by the National High-Tech R&D Program (863) of China (No. 2015AA020306)

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Xiang, By., Chen, L., Wang, Xj. et al. Mesenchymal stem cells as therapeutic agents and in gene delivery for the treatment of glioma. J. Zhejiang Univ. Sci. B 18, 737–746 (2017). https://doi.org/10.1631/jzus.B1600337

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  • DOI: https://doi.org/10.1631/jzus.B1600337

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