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Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies

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Abstract

Objective

To determine the association between tea consumption and the risk of stroke.

Methods

We searched the PubMed database from January 1966 to March 2012 and reviewed reference lists of retrieved articles to identify relevant studies. Studies were included if they reported relative risks (RRs) and corresponding 95% confidence intervals (CIs) of stroke with respect to three or more categories of tea consumption. A random-effects model was used to combine the study-specific risk estimates.

Results

Fourteen studies, consisting of 513 804 participants with a median follow-up of 11.5 years, were included in this meta-analysis. We observed a modest but statistically significant inverse association between tea consumption and risk of stroke. An increase of three cups/d in tea consumption was associated with a 13% decreased risk of stroke (RR 0.87; 95% CI, 0.81–0.94). The decreased risk of stroke with tea consumption was consistent among most subgroups. Based on the three studies that provided results for stroke subtypes, tea consumption was also inversely associated with the risk of ischemic stroke (RR 0.76; 95% CI, 0.69–0.84), but not cerebral hemorrhage (RR 0.96; 95% CI, 0.82–1.11) or subarachnoid hemorrhage (RR 0.81; 95% CI, 0.57–1.16).

Conclusions

Tea consumption is associated with a decreased risk of stroke, particularly ischemic stroke. More well-designed, rigorously conducted studies are needed in order to make confident conclusions about the association between tea consumption and stroke subtypes.

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Authors and Affiliations

  1. Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China

    Li Shen, Liu-guang Song, Hong Ma, Chun-na Jin, Jian-an Wang & Mei-xiang Xiang

  2. Cardiovascular Key Lab of Zhejiang Province, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China

    Li Shen, Liu-guang Song, Hong Ma, Chun-na Jin, Jian-an Wang & Mei-xiang Xiang

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  1. Li Shen
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  2. Liu-guang Song
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  3. Hong Ma
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Correspondence to Mei-xiang Xiang.

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Project (No. 2007C13058) supported by the Science and Technology Key Project of Zhejiang Province, China

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Shen, L., Song, Lg., Ma, H. et al. Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies. J. Zhejiang Univ. Sci. B 13, 652–662 (2012). https://doi.org/10.1631/jzus.B1201001

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  • DOI: https://doi.org/10.1631/jzus.B1201001

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