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Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model

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Abstract

In order to better understand biatrial conduction, investigate various conduction pathways, and compare the differences between isotropic and anisotropic conductions in human atria, we present a simulation study of biatrial conduction with known/assumed conduction pathways using a recently developed human atrial model. In addition to known pathways: (1) Bachmann’s bundle (BB), (2) limbus of fossa ovalis (LFO), and (3) coronary sinus (CS), we also hypothesize that there exist two fast conduction bundles that connect the crista terminalis (CT), LFO, and CS. Our simulation demonstrates that use of these fast conduction bundles results in a conduction pattern consistent with experimental data. The comparison of isotropic and anisotropoic conductions in the BB case showed that the atrial working muscles had small effect on conduction time and conduction speed, although the conductivities assigned in anisotropic conduction were two to four times higher than the isotropic conduction. In conclusion, we suggest that the hypothesized intercaval bundles play a significant role in the biatrial conduction and that myofiber orientation has larger effects on the conduction system than the atrial working muscles. This study presents readers with new insights into human atrial conduction.

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Authors and Affiliations

  1. College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, 310027, China

    Dong-dong Deng, Ying-lan Gong, Guo-fa Shou, Xue-song Ye & Ling Xia

  2. Institute of Clinical Anatomy, Southern Medical University, Guangzhou, 510515, China

    Pei-feng Jiao

  3. Biological Physics, University of Manchester, Manchester, M13 9PL, UK

    Heng-gui Zhang

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  1. Dong-dong Deng
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  2. Ying-lan Gong
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  7. Ling Xia
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Correspondence to Ling Xia.

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Project supported by the National Basic Research Program (973) of China (No. 2007CB512100), the National High-Tech R & D Program (863) of China (No. 2006AA02Z307), the National Natural Science Foundation of China (Nos. 81171421 and 61101046), and the Zhejiang Provincial Natural Science Foundation of China (No. Z1080300)

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Deng, Dd., Gong, Yl., Shou, Gf. et al. Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model. J. Zhejiang Univ. Sci. B 13, 676–694 (2012). https://doi.org/10.1631/jzus.B1100339

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