Abstract
For some time now, the research on gastric motility and function has fallen behind in the amount of research on gastric endocrine, exocrine secretion, and gastric morphology. In this paper, a noninvasive method to study gastric motility was developed, taking bioimpedance measurements over the gastric area simultaneously with the electrogastrography (EGG). This is based on the concept of observing and analyzing simultaneously the intrinsic electrical gastric activity (basic electric rhythm) and the mechanical gastric activity. Additionally, preliminary clinical studies of healthy subjects and subjects with functional dyspepsia (FD) and gastritis were carried out. The impedance gastric motility (IGM) measurements of the healthy and FD subjects were compared, along with the studies of the FD subjects before treatment and after one week and three weeks of treatment. We also compared IGM measurements of healthy subjects and subjects with erosive gastritis, along with the studies of the subjects with erosive gastritis before treatment and after one week of treatment. Results show that FD subjects have poor gastric motility (P<0.01). After a week of treatment, the gastric motility of FD subjects was not yet improved although the EGG had returned to normal by this time. By three weeks of treatment, the regular IGM rhythm returned in FD subjects. There was a significant difference of IGM parameters between the gastritis and healthy subjects (P<0.05). The EGG rhythm of the gastritis subjects returned to normal at one week post-treatment, while IGM parameters showed a trend to improvement (P>0.05), These results suggest the possibility of clinic application of the proposed method.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chaw, C.S., Yazaki, E., Evans, D.F., 2001. The effect of pH change on the gastric emptying of liquids measured by electrical impedance tomography and pH-sensitive radiotelemetry capsule. Int. J. Pharm., 227(1–2):167–175. [doi:10.1016/S0378-5173(01)00795-5]
Chen, J.D., Lin, X.M., Abo, M., 2000. Multi-channel Gastric Electrical Stimulation for the Acceleration of Gastric Emptying. First International Conference on Advances in Medical Signal and Information Processing. Bristol, UK, p.60–65. [doi:10.1049/cp:20000318]
Chen, R.X., Wan, D.R., 1992a. Abnormal impedance gastrogram and upper gastrointestinal symptom. Med. Biol. Eng. Comput., 29(Suppl.):14–15.
Chen, R.X., Wan, D.R., 1992b. Further Investigation of Reliability on Impedance Gastrograph for Continuous Measurement of Human Gastric Contractile Activity. Proceedings of the 8th International Conference on Electrical Bio-impedance. July, Kupio, Finland, p.151–152.
Deng, J., Zhao, S., Sha, H., Wang, Y., Ren, C.S., Li, Z.Y., 2008. Electrical Bioimpedance Method to Measure Gastric Motility Function. Proceedings of the 2nd International Conference on Bioinformatics and Biomedical Engineering. Shanghai, China, p.616–619. [doi:10.1109/ICBBE.2008.150]
Familoni, B.O., Kingma, Y.J., Bowes, K.L., 1987. Noninvasive assessment of human gastric motor function. IEEE Trans. Biomed. Eng., 34(1):30–36. [doi:10.1109/TBME.1987.326012]
Gajre, S.S., Anand, S., Singh, U., Saxena, R.K., 2006. Novel Method of Using Dynamic Electrical Impedance Signals for Noninvasive Diagnosis of Knee Osteoarthritis. Engineering in Medicine and Biology Society. 28th Annual International Conference of the IEEE. New York, NY, p.2207–2210. [doi:10.1109/IEMBS.2006.260671]
Garay, L., Ramos, E.G., Cardiel, E., Munoz, R., Hernandez, P.R., 2006. In vivo and in situ measurement of electrical impedance for determination of distention in proximal stomach of rats. Med. Eng. Phys., 28(7):648–655. [doi:10.1016/j.medengphy.2005.10.010]
Giouvanoudi, A.C., Spyrou, N.M., 2008. Epigastric electrical impedance for the quantitative determination of the gastric acidity. Physiol. Meas., 29(11):1305–1317. [doi:10.1088/0967-3334/29/11/006]
Giouvanoudi, A., Amaee, W.B., Sutton, J.A., Horton, P., Morton, R., Hall, W., Morgan, L., Freedman, M.R., Spyrou, N.M., 2003. Physiological interpretation of electrical impedance epigastrography measurements. Physiol. Meas., 24(1):45–55. [doi:10.1088/0967-3334/24/1/304]
Hadi, N.A., Giouvanoudi, A., Morton, R., Horton, P.W., Spyrou, N.M., 2002. Variations in gastric emptying times of three stomach regions for simple and complex meals using scintigraphy. IEEE Trans. Nucl. Sci., 49(5): 2328–2331. [doi:10.1109/TNS.2002.803785]
Huerta-Franco, R., Vargas-Luna, M., Hernandez, E., Capaccione, K., Cordova, T., 2009. Use of short-term bio-impedance for gastric motility assessment. Med. Eng. Phys., 31(7):770–774. [doi:10.1016/j.medengphy.2009.02.008]
Kothapalli, B., 1992. Origin of changes in the epigastric impedance signal as determined by a three-dimensional model. IEEE Trans. Biomed. Eng., 39(10):1005–1010. [doi:10.1109/10.161332]
Li, Z.Y., Ren, C.S., 2008. Gastric motility measurement and evaluation of functional dyspepsia by a bio-impedance method. Physiol. Meas., 29(6):S373–S382. [doi:10.1088/0967-3334/29/6/S31]
Li, Z.Y., Ren, C.S., 2009. Impedance gastric motility measurement to evaluate functional dyspepsia. Chin. J. Biomed. Eng., 28(3):372–376 (in Chinese).
Li, Z.Y., Sha, H., Wang, Y., Zhao, S., Wang, W., Ren, C.S., 2007. A New Approach of Gastric Motility Measurement and Evaluation by Bioimpedance. Proceedings of 13th International Conference on Electrical Bio-Impedance & 8th Conference on Electrical Impedance Tomography. Aug. 29, Graz, Austria, p.691–694.
Li, Z.Y., Sha, H., Zhao, S., Wang, Y., Ren, C.S., 2008. Liquid gastric emptying measurement using an electrical bio-impedance method. Chin. J. Med. Instrum., 32(4): 253–256 (in Chinese).
Liu, S.R., Li, Z.Y., Ren, C.S., Liu, C.L., Fang, X.J., 2009. Research on gastric motility for erosive gastritis. Chin. J. Med. Phys., 26(3):1224–1227 (in Chinese).
Ma, D.S., Zhou, B., Fu, B., Song, M., 2006. Gastrointestinal Motor and Clinical Aspects. Military Medicine Science Press, Beijing, p.37–44 (in Chinese).
Ren, C.S., Li, Z.Y., Zhao, S., 2010. Use of electrical bioimpedance for gastric motility measurement and evaluation. World Chin. J. Digestol., 18(1):1–8 (in Chinese).
Soulsby, C.T., Khela, M., Yazaki, E., Evans, D.F., Hennessy, E., Jeremy, P.T., 2006. Measurements of gastric emptying during continuous nasogastric infusion of liquid feed: electric impedance tomography versus gamma scintigraphy. Clin. Nutr., 25(4):671–680. [doi:10.1016/j.clnu.2005.11.015]
Sutton, J.A., Thompson, S., 1985. Measurement of gastric emptying rates by radioactive isotope scanning and epigastric impedance. The Lancet, 325(8434):898–900. [doi:10.1016/S0140-6736(85)91674-5]
Zhou, L., Ke, M.Y., 2005. Textbook of Neurogastroenterology and Motility, Basic and Clinical Aspects. Science Press, Beijing, p.501–521 (in Chinese).
Author information
Authors and Affiliations
Corresponding author
Additional information
Project (Nos. 60471041 and 60901045) supported by the National Natural Science Foundation of China
Rights and permissions
About this article
Cite this article
Li, Zy., Ren, Cs., Zhao, S. et al. Gastric motility functional study based on electrical bioimpedance measurements and simultaneous electrogastrography. J. Zhejiang Univ. Sci. B 12, 983–989 (2011). https://doi.org/10.1631/jzus.B1000436
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1631/jzus.B1000436