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Mathematical models of canine right and left atria cardiomyocytes

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Abstract

The aim of this study is to build two mathematical models of canine ionic currents specific to right atria and left atria. The canine left atria mathematical model was firstly modified from the Ramirez-Nattel-Courtemanche (RNC) model using the recently available experimental data of ionic currents and was further developed based on our own experimental data. A model of right atria was then built by considering the differences between right atria and left atria. The two developed models well reproduced the experimental data on action potential morphology, the rate dependence, and action potential duration restitution. They are useful for investigating the mechanisms underlying the heterogeneity of canine regional action potentials and would help the simulation of whole heart excitation propagation and cardiac arrhythmia in the near future.

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Authors and Affiliations

  1. Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China

    Ling Xia, Ying-lan Gong, Xiu-wei Zhu & Yu Zhang

  2. Center of Arrhythmia Diagnosis and Treatment, Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100037, China

    Qi Sun

  3. Biological Physics Group, School of Physics and Astronomy, The University of Manchester, Manchester, M13 9PL, UK

    Heng-gui Zhang

Authors
  1. Ling Xia
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  2. Ying-lan Gong
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  3. Xiu-wei Zhu
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  4. Yu Zhang
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  5. Qi Sun
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  6. Heng-gui Zhang
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Correspondence to Ling Xia.

Additional information

Project supported by the National Basic Research Program (973) of China (No. 2007CB512100), the National High-Tech R & D Program (863) of China (No. 2006AA02Z307), and the National Natural Science Foundation of China (No. 30570484)

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Xia, L., Gong, Yl., Zhu, Xw. et al. Mathematical models of canine right and left atria cardiomyocytes. J. Zhejiang Univ. Sci. B 11, 402–416 (2010). https://doi.org/10.1631/jzus.B0900346

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  • DOI: https://doi.org/10.1631/jzus.B0900346

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