Abstract
Objective
To explore clinical and laboratory features and significance of detecting serum carbohydrate antigen 125 (CA125) in immunoglobulin E (IgE) multiple myeloma.
Methods
We reported the clinical findings of a male patient with IgE myeloma and elevated level of serum CA125 and reviewed the literature.
Results
Laboratory tests of this patient on admission showed extremely high serum IgE and CA125, a bone marrow aspirate revealed abnormal plasma cells (38.4% of nucleated cells: 16.4% mature and 22% atypical), and in bone marrow biopsy, immunoperoxidase staining showed positive cytoplasmic staining for IgE and κ light chain within the vast majority of plasma cells. Computed tomography (CT) bone scans indicated wedge shape change and compressive fracture of thoracic vertebrae, and emission computed tomography (ECT) discovered multiple punctiform aggregation of radiation in both cervical ribs and spine. The serum IgE and CA125 gradually decreased to normal limits after eight cycles of chemotherapy. This patient is alive well with an 18-month complete remission.
Conclusion
We reported the first case of IgE myeloma with elevated level of serum CA125. To further evaluate clinical characteristics and significance of CA125 in IgE myeloma, more cases are needed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alexander, R.L.Jr., Roodman, S.T., Petruska, P.J., Tsai, C.C., Janney, C.G., 1992. A new case of IgE myeloma. Clin. Chem., 38(11):2328–2332.
de Rossi, G., de Sanctis, G., Bottari, V., Tribalto, M., Lopez, M., Petrucci, M.T., Fontana, L., 1987. Surface markers and cytotoxic activities of lymphocytes in monoclonal gammopathy of undetermined significance and untreated multiple myeloma. Increased phytohemagglutinin-induced cellular cytotoxicity and inverted helper/suppressor cell ratio are features common to both diseases. Cancer Immunol. Immunother., 25(2):133–136.
Dilek, I., Ayakta, H., Demir, C., Meral, C., Ozturk, M., 2005. CA125 levels in patients with non-Hodgkin lymphoma and other hematologic malignancies. Clin. Lab. Haematol., 27(1):51–55. [doi:10.1111/j.1365-2257.2004.00655.x]
Eagle, K., Ledemann, J., 1997. Tumor markers in ovarian malignancies. Oncology, 2(5):324–329.
Gallango, M.L., Suinaga, R., Ramirez, M., 1988. IgE pyroglobulinemia in multiple myeloma. Clin. Chim. Acta, 176(2):151–156. [doi:10.1016/0009-8981(88)90202-1]
Galton, D.A.G., Peto, R., 1973. Report on the first myelomatosis trial. Part 1. Analysis of presenting features of prognostic importance. Br. J. Haematol., 24(1):123–139. [doi:10.1111/j.1365-2141.1973.tb05733.x]
Jako, J.M., Gesztesi, T., Kaszas, I., 1997. IgE lamda monoclonal gammopathy and amyloidosis. Int. Arch. Allergy Immunol., 112(4):415–421.
Johansson, S.G., Bennich, H., 1967. Immunological studies of an atypical (myeloma) immunoglobulin. Immunology, 13(4):381–394.
Kairemo, K.J., Lindberg, M., Prytz, M., 1999. IgE myeloma: a case presentation and a review of the literature. Scand. J. Clin. Lab. Invest., 59(6):451–456. [doi:10.1080/00365519950185472]
Kimura, J., Suzuki, N., Tomioka, H., Takahashi, H., 1981. A case of IgE myeloma. Rinsho. Ketsueki., 22(9):1469–1477 (in Japanese).
Koh, T., Ohno, T., Kageyama, S., Shimizu, N., Uchida, T., Tanaka, I., Kobayashi, T., Karitani, Y., Shirakawa, S., 1986. IgE multiple myeloma. A case report and review of the literature. Nippon. Ketsueki. Gakkai. Zasshi., 49(3):696–702 (in Japanese).
Lloyd, L., Klingberg, S.L., Kende, M., Howell, J.F., Clague, A.E., 2003. A case of IgE multiple myeloma. Pathology, 35(1):87–89. [doi:10.1080/0031302021000062424]
Ludwig, H., Vormittag, W., 1980. “Benign” monoclonal IgE gammopathy. BMJ, 281(6239):539–540. [doi:10.1136/bmj.281.6239.539]
Russo, F., Lastoria, S., Svanera, G., Capobianco, G., de Chiara, A., Francia, R., Squame, E., de Martinis, F., Pinto, A., 2007. Long-term follow-up study on the role of serum CA-125 as a prognostic factor in 221 newly diagnosed patients with Hodgkin’s lymphoma. Leuk. Lymphoma, 48(4):723–730. [doi:10.1080/10428190601183710]
San Miguel, J.F., Caballero, M.D., Gonzalez, M., 1985. T-cell subpopulations in patients with monoclonal gammopathies: essential monoclonal gammopathy, multiple myeloma, and Waldenstroms macroglobulinemia. Am. J. Hematol., 20(3):267–273. [doi:10.1002/ajh.2830200308]
van Wijk, H.J., Kerckhaert, J.A., Oei, O.L., van Helden, H.P., 1986. Immunoglobulin E myeloma. Case report and review of the literature. Neth. J. Med., 29(6):196–200.
Vladutiu, A.O., Kohli, R.K., Prezyna, A.P., 1976. Monoclonal IgE with renal failure. Am. J. Med., 61(6):957–962. [doi:10.1016/0002-9343(76)90422-8]
Yoshitake, J., Hiramatsu, S., Komatsubara, Y., Matsubara, T., Fujita, T., 1976. A case of IgE myeloma. Acta Haematol. Jpn, 39(6):862–875 (in Japanese).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wang, Ml., Huang, Q. & Yang, Tx. IgE myeloma with elevated level of serum CA125. J. Zhejiang Univ. Sci. B 10, 559–562 (2009). https://doi.org/10.1631/jzus.B0820399
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1631/jzus.B0820399