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Abnormalities of masseter inhibitory reflex in patients with episodic tension-type headache

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Abstract

Objective

To investigate the masseter inhibitory reflex (MIR) and its eventual changes in patients with episodic tension-type headache (TTH).

Methods

MIR was studied in 21 patients with episodic TTH and 30 healthy subjects, with age and sex matched to the study cohort. Median age of patients was 17.0 years (ranged 16∼49 years), median duration of disease 12 months (1∼5 years), and median frequency of headache 7.5 d per month.

Results

The second period of suppression (S2) of MIR was reduced in intensity and duration in 10% of controls and 66.7% (confidence interval (CI)=45.3%∼85%; P<0.05) of patients with episodic TTH (χ2=74.9; P<0.001). In 3 (14.3%) of patients with episodic TTH, S2 was completely absent. No significant correlation between the duration of disease and headache frequency was found.

Conclusion

Our results confirm the link between episodic TTH and reduction or absence of S2. Teenage patients with episodic TTH may exhibit marked pathological changes in S2 in contrast to older individuals.

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References

  • Aktekin, B., Yaltkaya, K., Ozkaynak, S., Oguz, Y., 2001. Recovery cycle of the blink reflex and exteroceptive suppression of temporalis muscle activity in migraine and tension-type headache. Headache, 41(2):142–149. [doi:10.1046/j.1526-4610.2001.111006142.x]

    Article  PubMed  CAS  Google Scholar 

  • Cruccu, G., Cruccu, G., Agostino, R., Inghilleri, M., Manfredi, M., Ongerboer de Visser, B.W., 1989. The masseter inhibitory reflex is evoked by innocuous stumuli and mediated by A beta afferent fibers. Exp. Brain Res., 77(2):447–450. [doi:10.1007/BF00275005]

    Article  PubMed  CAS  Google Scholar 

  • Di Clemente, L., Coppola, G., Magis, D., Fumal, A., De Pasqua, V., Di Piero, V., Schoenen, J., 2007. Interictal habituation deficit of the nociceptive blink reflex: an endophenotypic marker for presymptomatic migraine? Brain, 130(3):765–770. [doi:10.1093/brain/awl351]

    Article  PubMed  Google Scholar 

  • Göbel, H., Dworschak, M., 1996. Exteroceptive suppression of activity of the temporal muscle. Principles and applications. Der Nervenarzt, 67(10):846–859. [doi:10.1007/s001150050062]

    Article  PubMed  Google Scholar 

  • Göbel, H., Dworschak, M., Wallasch, T.M., 1993. Exteroceptive suppression of temporalis muscle activity: perspectives in headache and pain research. Cephalalgia, 13(1):15–19. [doi:10.1046/j.1468-2982.1993.1301015.x]

    Article  PubMed  Google Scholar 

  • Headache Classification Subcommittee of the International Headache Society, 2004. The international classification of headache disorders, 2nd Ed. Cephalalgia, 24(Suppl. 1):9–160.

    Google Scholar 

  • Lipchik, G., Holroyd, K.A., O’Donnel, F.J., Cordinqley, G.E., Waller, S., Labus, J., Davis, M.K., French, D.J., 2000. Exteroceptive suppression periods and pericranial muscle tenderness in chronic tension headache: effects of psychopathology, chronicity and disability. Cephalalgia, 20(7):638–646. [doi:10.1046/j.1468-2982.2000.00105.x]

    Article  PubMed  CAS  Google Scholar 

  • Miles, T.S., Türker, K.S., Nordstrom, M.A., 1987. Reflex responses of motor units in human masseter muscle to electrical stimulation of the lip. Exp. Brain Rres., 65(2):331–336. [doi:10.1007/BF00236305]

    CAS  Google Scholar 

  • Neufeld, J.D., Holroyd, K.A., Lipchik, G.L., 2000. Dynamic assessment of abnormalities in central pain transmission and modulation in tension-type headache sufferers. Headache, 40(2):142–151. [doi:10.1046/j.1526-4610.2000.00020.x]

    Article  PubMed  CAS  Google Scholar 

  • Ongerboer de Visser, B.W., Cruccu, G., Manfredi, M., Koelman, J.H., 1990. Effects of brainstem lesions on the masseter inhibitory reflex: functional mechanisms of reflex pathways. Brain, 113(3):781–792. [doi:10.1093/brain/113.3.781]

    Article  PubMed  Google Scholar 

  • Paulus, W., Raubüchl, O., Straube, A., Schoenen, J., 1992. Exteroceptive suppression of temporalis muscle activity in various types of headache. Headache, 32(1):41–44. [doi:10.1111/j.1526-4610.1992.hed3201041.x]

    Article  PubMed  CAS  Google Scholar 

  • Raudino, F., 1994. Is temporomandibular dysfunction a cranial dystonia? An electrophysiological study. Headache, 34(8):471–475. [doi:10.1111/j.1526-4610.1994.hed3408471.x]

    Article  PubMed  CAS  Google Scholar 

  • Schoenen, J., 1993. Exteroceptive suppression of temporalis muscle activity: methodological and physiological aspects. Cephalalgia, 13(1):3–10. [doi:10.1046/j.1468-2982.1993.1301003.x]

    Article  PubMed  CAS  Google Scholar 

  • Schoenen, J., Agrégé, M.D., 1993. Exteroceptive suppression of temporalis muscle activity in patients with chronic headache and in normal volunteers: methodology, clinical and pathophysiological relevance. Headache, 33(1):3–17. [doi:10.1111/j.1526-4610.1993.hed3301003.x]

    Article  PubMed  CAS  Google Scholar 

  • Schoenen, J., Bottin, D., Sulon, J., Gaspard, U., Lambotte, R., 1991. Exteroceptive silent period of temporalis muscle in menstrual headache. Cephalalgia, 11(2):87–91. [doi:10.1046/j.1468-2982.1991.1102087.x]

    Article  PubMed  CAS  Google Scholar 

  • Wallasch, T.M., 1991. A study on the exteroceptive suppression of the masseter, temporalis and trapezius muscles produced by mental nerve stimulation in patients with chronic headaches. Cephalalgia, 11(3):162–163. [doi:10.1046/j.1468-2982.1991.1103160.x]

    PubMed  CAS  Google Scholar 

  • Wallasch, T.M., Göbel, H., 1993. Exteroceptive suppression of temporalis muscle activity: findings in headache. Cephalalgia, 13(1):11–14. [doi:10.1046/j.1468-2982.1993.1301011.x]

    Article  PubMed  CAS  Google Scholar 

  • Wallasch, T.M., Reinecke, M., Langohr, H.D., 1991. EMG analysis of the late exteroceptive suppression period of temporal muscle activity in episodic and chronic tensiontype headaches. Cephalalgia, 11(2):109–112. [doi:10.1046/j.1468-2982.1991.1102109.x]

    Article  PubMed  CAS  Google Scholar 

  • Wallasch, T.M., Niemann, U., Kropp, P., Weinschütz, T., 1993. Exteroceptive silent periods of temporalis muscle activity: correlation with neuropsychological findings. Headache, 33(3):121–124. [doi:10.1111/j.1526-4610.1993.hed3303121.x]

    Article  PubMed  CAS  Google Scholar 

  • Wang, W., Schoenen, J., 1994. Reduction of temporalis exteroceptive suppression by peripheral electrical stimulation in migraine and tension-type headaches. Pain, 59(3):327–334. [doi:10.1016/0304-3959(94)90018-3]

    Article  PubMed  CAS  Google Scholar 

  • Wang, W., de Pasqua, V., Gerard, P., Schoenen, J., 1995. Specificity and sensitivity of temporalis ES2 measurements in the diagnosis of chronic primary headaches. Headache, 35(2):85–88. [doi:10.1111/j.1526-4610.1995.hed3502085.x]

    Article  PubMed  CAS  Google Scholar 

  • Woolf, N.J., 1991. Cholinergic systems in mammalian brain and spinal cord. Prog. Neurobiol., 37(6):475–524. [doi:10.1016/0301-0082(91)90006-M]

    Article  PubMed  CAS  Google Scholar 

  • Yemm, R., 1972. Reflex jau opening following electrical stimulation of oral mucose membrane in man. Arch. Oral Biol., 17(3):513–523. [doi:10.1016/0003-9969(72)90067-2]

    Article  PubMed  CAS  Google Scholar 

  • Yu, S.K., Schmitt, A., Sessle, B.J., 1973. Inhibitory effects on jaw muscle activity of innocuous and nocuous stimulation of facial and intraoral sites in man. Arch. Oral Biol., 18(7):861–870. [doi:10.1016/0003-9969(73)90056-3]

    Article  PubMed  CAS  Google Scholar 

  • Zwart, J.A., Sand, T., 1995. Exteroceptive suppression of temporalis muscle activity: a blind study of tension-type headache, migraine, and cervicogenic headache. Headache, 35(6):338–343. [doi:10.1111/j.1526-4610.1995.hed3506338.x]

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Plamen Tzvetanov.

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Tzvetanov, P., Rousseff, R.T. & Radionova, Z. Abnormalities of masseter inhibitory reflex in patients with episodic tension-type headache. J. Zhejiang Univ. Sci. B 10, 52–56 (2009). https://doi.org/10.1631/jzus.B0820249

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  • DOI: https://doi.org/10.1631/jzus.B0820249

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