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Persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis

Abstract

This study was designed to investigate persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis. Milk samples were collected at a 1-d interval after the last administration from 34 individual cows that had received intramammary infusions of gentamicin. The doses and treatment times evaluated in this study represented those that have been applied by veterinarians in practice. The tetrazolium chloride assay was used to determine whether there were significant residues of the antibiotic in the samples. Persistence of detectable drug residues in milk from 33 cows (28 cows, ≤6 infusions at ≤0.7 g gentamicin; and 5 cows, 2 infusions at 0.8 g gentamicin) did not exceed 5 d; but 1 cow (5 infusions at 0.8 g gentamicin) had detectable residues in its milk for 9 d. Our results suggest that a 5-d milk withdrawal period might be insufficient to secure the clearance of the contamination of gentamicin, because treatment times and dosages contribute to the antibiotic clearance. A larger scale of samples are needed for further investigations.

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Correspondence to Song-hua Hu.

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Project supported by the Science and Technology Department of Zhejiang Province (Nos. 2005C12015 and 2007C32025) and the Education Department of Zhejiang Province (No. 20061319), China

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Tan, X., Jiang, Yw., Huang, Yj. et al. Persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis. J. Zhejiang Univ. Sci. B 10, 280–284 (2009). https://doi.org/10.1631/jzus.B0820198

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  • DOI: https://doi.org/10.1631/jzus.B0820198

Key words

  • Gentamicin
  • Mastitis
  • Intramammary infusion
  • Residue

CLC number

  • R15