Skip to main content

Deep lingual arterial chemoembolization of tongue carcinoma with microcapsuled anticancer drug

Abstract

Objective

Microcapsule chemoembolism is a promising treatment of tumors. We describe a deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum.

Methods

Lingual artery cast specimens from cadavers were microscopically examined, and 78 patients with tongue cancer were recruited and treated with the deep lingual arterial embolization therapy.

Results

Microcapsule embolism occurred approximately at the fifth or sixth level of the deep lingual artery branches. The five-year survival rate was 88.5% (69 out of 78), and the ten-year survival rate 52.6% (41 out of 78).

Conclusion

The deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum is an effective therapy to treat carcinoma in mid-margin or mid-body of the tongue.

This is a preview of subscription content, access via your institution.

References

  • Diaco, D.S., Hajarizadeh, H., Mueller, C.R., Fletcher, W.S., Pommier, R.F., Woltering, E.A., 1995. Treatment of metastatic carcinoid tumors using multimodality therapy of octreotide acetate, intra-arterial chemotherapy, and hepatic arterial chemoembolization. Am. J. Surg., 169(5):523–528. [doi:10.1016/S0002-9610(99)80210-4]

    PubMed  Article  CAS  Google Scholar 

  • Dockery, P., Fraher, J., 2007. The quantification of vascular beds: a stereological approach. Exp. Mol. Pathol., 82(2):110–120. [doi:10.1016/j.yexmp.2006.12.011]

    PubMed  Article  CAS  Google Scholar 

  • Esteban, J.M., Gil, J., 2002. Therapeutic effect of chemoembolization therapy on hepatocellular carcinoma: evaluation with contrast-enhanced power Doppler sonography and contrast-enhanced harmonic imaging. Acad. Radiol., 9(2):s382–s383. [doi:10.1016/S1076-6332(03)80238-6]

    PubMed  Article  Google Scholar 

  • Gu, G.H., Huang, J.Q., He, H., 2002. Sequential-release of anticancer drugs microcapsulated with ethylcellulose. Chin. Med. J., 115(11):1730–1732.

    PubMed  CAS  Google Scholar 

  • Harris, M., Gibbs, P., Cebon, J., Jones, R., Sewell, R., Schelleman, T., Angus, P., 2001. Hepatocellular carcinoma and chemoembolization. Intern. Med. J., 31(9):517–522. [doi:10.1046/j.1445-5994.2001.00131.x]

    PubMed  Article  CAS  Google Scholar 

  • Hayashi, P.H., Ludkowski, M., Forman, L.M., Osgood, M., Johnson, S., Kugelmas, M., 2004. Hepatic artery chemoembolization for hepatocellular carcinoma in patients listed for liver transplantation. Am. J. Transplant., 4(5):782–787. [doi:10.1111/j.1600-6143.2004.00413.x]

    PubMed  Article  Google Scholar 

  • Huang, Y.H., Wu, J.C., Chen, S.C., Chen, C.H., Chang, J.H., Huo, T.I., 2006. Survival benefit of transcatheter arterial chemoembolizaton in patients with hepatocellular carcinoma larger than 10 cm in diameter. Aliment. Pharmacol. Ther., 23(1):129–135. [doi:10.1111/j.1365-2036.2006.02704.x]

    PubMed  Article  Google Scholar 

  • Iguchi, H., Kusuki, M., Nakamura, A., Kanazawa, A., Hachiya, K., Yamane, H., 2006. Outcome of preoperative concurrent chemoradiotherapy and surgery for resectable lingual squamous cell carcinoma greater than 3 cm: the possibility of less extensive surgery. Oral Oncol., 42(4):391–397. [doi:10.1016/j.oraloncology.2005.09.006]

    PubMed  Article  CAS  Google Scholar 

  • Jang, M.K., Lee, H.C., Kim, I.S., Lim, Y.S., Chung, Y.H.W.A., Lee, Y.S., 2004. Role of additional angiography and chemoembolization in patients with hepatocellular carcinoma who achieved complete necrosis following transarterial chemoembolization. J. Gastroenterol. Hepatol., 19(9):1074–1080. [doi:10.1111/j.1440-1746.2004.03414.x]

    PubMed  Article  Google Scholar 

  • Kato, T., Nemoto, R., Mori, H., Takahashi, M., Harada, M., 1981. Arterial chemoembolization with mitomycin C microcapsules in the treatment of primary or secondary carcinoma of the kidney, liver, bone and intrapelvic organs. Cancer, 48(3):674–680. [doi:10.1002/1097-0142(19810801)48:3〈674::AID-CNCR2820480303〉3.0.CO;2-E]

    PubMed  Article  CAS  Google Scholar 

  • Kimura, Y., Ariji, Y., Gotoh, M., Toyoda, T., Kato, M., Kawamata, A., 2001. Doppler sonography of the deep lingual artery. Acta Radiol., 42(3):306–311. [doi:10.1080/028418501127346693]

    PubMed  Article  CAS  Google Scholar 

  • Kovács, A.F., Turowski, B., 2002. Chemoembolization of oral and oropharyngeal cancer using a high-dose cisplatin crystal suspension and degradable starch microspheres. Oral Oncol., 38(1):87–95. [doi:10.1016/S1368-8375(01)00088-4]

    PubMed  Article  Google Scholar 

  • Munro, N.P., Woodhams, S., Nawrocki, J.D., Fletcher, M.S., Thomas, P.J., 2003. The role of transarterial embolization in the treatment of renal cell carcinoma. BJU Int., 92(3):240. [doi:10.1046/j.1464-410X.2003.04314.x]

    PubMed  Article  CAS  Google Scholar 

  • Ross, C.J.D., Chang, P.L., 2002. Development of small alginate microcapsules for recombinant gene product delivery to the rodent brain. J. Biomater. Sci. Polym. Ed., 13(8):953–962. [doi:10.1163/156856202320401988]

    PubMed  Article  CAS  Google Scholar 

  • Ruben, R.P., Tim, O.L., Murat, B., Corrina, C.M.M., Timm, K., Michael, G., 2005. Prospective analysis of German patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization with or without prophylactic antibiotic therapy. J. Gastroenterol. Hepatol., 20(7):1134.

    Article  Google Scholar 

  • Shang, Z.J., Li, Z.B., Li, J.R., 2006. VEGF is up-regulated by hypoxic stimulation and related to tumour angiogenesis and severity of disease in oral squamous cell carcinoma: in vitro and in vivo studies. Int. J. Oral Maxillofac. Surg., 35(6):533–538. [doi:10.1016/j.ijom.2005.09.006]

    PubMed  Article  Google Scholar 

  • Sun, C.X., Yang, M.D., Huang, J.Q., Zhang, M., 1997. The scanning electronic microscope study of human lingual artery cast model. Chin. J. Stomatol., 32(3):190 (in Chinese).

    Google Scholar 

  • Tsurumaru, D., Kuroiwa, T., Yabuuchi, H., Hirata, H., Higaki, Y., Tomita, K., 2007. Efficacy of intra-arterial infusion chemotherapy for head and neck cancers using coaxial catheter technique: initial experience. Cardiovasc. Intervent. Radiol., 30(2):207–211. [doi:10.1007/s00270-005-0272-0]

    PubMed  Article  Google Scholar 

  • Uehara, M., Sano, K., Ikeda, H., Sekine, J., Irie, A., Toyota, T., 2004. Expression of vascular endothelial growth factor and prognosis of oral squamous cell carcinoma. Oral Oncol., 40(3):321–325. [doi:10.1016/j.oraloncology.2003.08.020]

    PubMed  Article  CAS  Google Scholar 

  • Uraki, J., Yamakado, K., Nakatsuka, A., Takeda, K., 2004. Transcatheter hepatic arterial chemoembolization for hepatocellular carcinoma invading the portal veins: therapeutic effects and prognostic factors. Eur. J. Radiol., 51(1):12–18. [doi:10.1016/S0720-048X(03)00219-5]

    PubMed  Article  Google Scholar 

  • Veness, M.J., 1999. Tongue cancer in younger patients. Aust. Radiol., 43(1):76–82. [doi:10.1046/j.1440-1673.1999.00606.x]

    Article  CAS  Google Scholar 

  • Veness, M.J., Morgan, G.J., Sathiyaseelan, Y., Gebski, V., 2003. Anterior tongue cancer: age is not a predictor of outcome and should not alter treatment. ANZ J. Surg., 73(11):899–905. [doi:10.1046/j.1445-2197.2003.02818.x]

    PubMed  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ping Fei-yun.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

He, H., Huang, Jq., Ping, Fy. et al. Deep lingual arterial chemoembolization of tongue carcinoma with microcapsuled anticancer drug. J. Zhejiang Univ. - Sci. B 8, 704–708 (2007). https://doi.org/10.1631/jzus.2007.B0704

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1631/jzus.2007.B0704

Key words

  • Tongue carcinoma
  • Artery cast
  • Arterial chemoembolization
  • Deep lingual arterial embolization
  • Anticancer drug
  • Carboplatinum

CLC number

  • R739.8