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Maximal sequence length of exact match between members from a gene family during early evolution

  • Biotechnology
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Abstract

Mutation (substitution, deletion, insertion, etc.) in nucleotide acid causes the maximal sequence lengths of exact match (MALE) between paralogous members from a duplicate event to become shorter during evolution. In this work, MALE changes between members of 26 gene families from four representative species (Arabidopsis thaliana, Oryza sativa, Mus musculus and Homo sapiens) were investigated. Comparative study of paralogous’ MALE and amino acid substitution rate (dA<0.5) indicated that a close relationship existed between them. The results suggested that MALE could be a sound evolutionary scale for the divergent time for paralogous genes during their early evolution. A reference table between MALE and divergent time for the four species was set up, which would be useful widely, for large-scale genome alignment and comparison. As an example, detection of large-scale duplication events of rice genome based on the table was illustrated.

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Authors and Affiliations

  1. Institute of Crop Science, Zhejiang University, 310029, Hangzhou, China

    Wen Xiao & Long-jiang Fan

  2. Institute of Bioinformatics/IBM Biocomputational Lab, Zhejiang University, 310029, Hangzhou, China

    Xing-yi Guo & Long-jiang Fan

Authors
  1. Wen Xiao
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  2. Xing-yi Guo
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  3. Long-jiang Fan
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Correspondence to Long-jiang Fan.

Additional information

Project supported by the National Natural Science Foundation of China (Grant Nos. 30270810, 90208022 and 30471067) and IBM Shared University Research (Life Science), China

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Wen, X., Guo, Xy. & Fan, Lj. Maximal sequence length of exact match between members from a gene family during early evolution. J Zheijang Univ Sci B 6, 470–476 (2005). https://doi.org/10.1631/jzus.2005.B0470

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  • DOI: https://doi.org/10.1631/jzus.2005.B0470

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