Abstract
Objective: To characterize the expression of aquaporin-4 (AQP4), one of the aquaporins (AQPs), in human brain specimens from patients with traumatic brain injury or brain tumors. Methods: Nineteen human brain specimens were obtained from the patients with traumatic brain injury, brain tumors, benign meningioma or early stage hemorrhagic stroke. MRI or CT imaging was used to assess brain edema. Hematoxylin and eosin staining were used to evaluate cell damage. Immunohistochem-istry was used to detect the AQP4 expression. Results: AQP4 expression was increased from 15 h to at least 8 d after injury. AQP4 immunoreactivity was strong around astrocytomas, ganglioglioma and metastatic adenocarcinoma. However, AQP4 immunore-activity was only found in the centers of astrocytomas and ganglioglioma, but not in metastatic adenocarcinoma derived from lung. Conclusion: AQP4 expression increases in human brains after traumatic brain injury, within brain-derived tumors, and around brain tumors.
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Project supported by the National Natural Science Foundation of China (No. 30271498) and the National Basic Research Program (973) of China (No. G1999054000)
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Hu, H., Yao, Ht., Zhang, Wp. et al. Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors. J Zheijang Univ Sci B 6, 33–37 (2005). https://doi.org/10.1631/jzus.2005.B0033
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DOI: https://doi.org/10.1631/jzus.2005.B0033
Key words
- Aquaporin-4 (AQP4)
- Traumatic brain injury
- Astrocytoma
- Ganglioglioma
- Metastatic adenocarcinoma
- Brain edema