Abstract
Objective: To gain further understanding of the antiphospholipid syndrome (APS). Methods: Analysing clinical and laboratory data on ten cases of APS. Results: Thrombocytopenia appeared in all cases. Venous thrombi of limbs appeared in five cases and neurological abnormalities in two cases. Renal impairments were found in three cases. One case manifested left renal venous thrombi and the other two cases thrombotic microangiopathy. Budd-Chiari syndrome was found in one case. One of the ten cases was catastrophic APS (CAPS) presented as acute diffuse swelling, cyanosis, pain, ischemia and necrosis in fingers and limbs, recurrent shock, ascites, hepatic and respiratory dysfunction. Anticoagulants and corticosteroids could be effective foctive for dealing with APS. It was critical to treat catastrophic APS with anticoagulants or plasmapheresis as early as possible. Conclusion: APS shows variable manifestations for good prognosis, but catastrophic APS has fatal risk. The main treatment for APS is the use of anticoagulants and immunosuppressives.
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References
Alarcon-Segovia, D., Deleze, M., Oria, C. V., Sanchez-Guerrero, J., Gomez-Pacheco, L., Cabiedes, J., Fernandez, L. and Ponce-de-Leon, S., 1989. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus: a prospective analysis of 500 consecutive patients.Medicine (Baltimore),68: 353–365.
Amigo, M. C., Garcia-Torres, T. and Robles, M., Bochicchio, T. and Reyes, P. A., 1992. Renal involvement in primary antiphospholipid syndrome.J Rheumatol,19: 1181–1185.
Asherson, R. A. and Piette, J. C., 1996. The catastrophic antiphospholipid syndrome: acute multi-organ failure associated with antiphospholipid antibodies: a review of 31 patients.Lupus,5: 414–417.
Greisman, S. G., Thayaparan, R. S., Godwin, T. A. and Lockshin, M. D., 1991. Occlusive vasculopathy in systemic lupus erythematosus (association with anticardiolipin antibody).Arch Intern Med,151: 389–392.
Harris, E. N., Phil, M. and Bos, D. M. K. 1991. An acute disseminated coagulopathy-vasculopathy associated with the antiphospholipid syndrome (editorial).Arch Intern Med,151: 231–233.
He, J., Wang, J. B. and Tang, F. L., 1996. One case of Budd-Chiari syndrome caused by antiphospholipid antibody.Chinese journal of internal medicine,35: 31.
Jiang, M., Zhu, L. P. and Lin, X. Y., 1995. Rheumatology. Science Publishing Company, Beijing, p. 1547–1561.
Pangborn, M. C., 1941. A new serologically active phospholipid from beef heart.Pro Soc Exp Biol Med,48: 484–486.
Pomeroy, C., Knodell, R. G., Swaim, W. R., Arneson, P. and Mahowald, M. L., 1984. Budd-Chiari syndrome in patient with the lupus anticoagulant.Gastroenterology,86: 158–161.
Triptt, D. A. and Asherson, R. A., 2000. Pathophysiology of the catastrophic antiphospholipid syndrome (CAPS).Am. J. Hematol.,65: 154–159.
Wilson, W. A., Gharavi, A. E., Koike, T., Lockshin, M. D., Branch, D. W., Piette, J. C., Brey, R., Derksen, R., Harris, E. N., Hughes, G. R., Triplett, D. A. and Khamashta, M. A., 1999. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop.Arthritis Rheum,42: 1309–1311.
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Li-hua, C., Ling-ling, J., You-ming, L. et al. Antiphospholipid syndrome: a survey of clinical characters in ten cases. J. Zhejiang Univ. Sci. A 4, 616–619 (2003). https://doi.org/10.1631/jzus.2003.0616
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DOI: https://doi.org/10.1631/jzus.2003.0616