Abstract
This study was aimed to investigate the level of sEGF in CAG with different therapies of either Chinese traditional medicine or western medicine. Patients were divided into spleen-reinforcing I, spleen-reinforcing II, dampness-resolving and western medicine group by Differentiation Syndrome. Healthy volunteers acted as controls. The sEGF was investigated before and after treatment. The level of sEGF in CAG was higher than that in control group(P < 0.01). In patients of spleen-reinforcing I group and spleen-reinforcing II group, the symptoms and pathological manifestations were improved dramatically (P < 0.01) and sEGF dropped markedly after treatment(P < 0.01 and P < 0.05). The level of sEGF in the dampness-resolving group increased after treatment (P < 0.05). But the level of sEGF in the western-medicine group dropped a little after treatment (P > 0.05). The inflammation of gastric mucosa may cause the elevation of sEGF in CAG reflectively. After being effectively treated with Chinese traditional medicine, the symptoms of CAG improved simultaneously with the return of sEGF. SEGF is a sensitive index to prognosis of CAG.
References
Chen Haozhu, 1996. Internal Medicine. The People’s Medical Publishing House, Beijing, p. 360–364 (in Chinese).
Elliott, S. N., Wallace, J. L., McKnight, W. et al., 2000. Bacterial colonization and healing of gastric ulcers: the effects of epidermal growth factor. Am J Physiol Gastrointest Liver Physiol, 278: G105–112.
Kanagihara, K., Kamada, N., Tsumuraya, M., et al., 1993. Establishment and characterization of a human gastric scirrhous carcinoma cell line in serum free chemically defined medium. Int J Cancer. 54(8): 200–207.
Land H., Parada, L. F., Weinberg, R. A. et al., 1983. Cellular oncogenes and multistep carcinogenesis. Science, 272: 771–778.
Piotrowski, J., Czajkowski, A., Yotsumoto, F., et al., 1993. Effect of ebrotidine on gastric mucosal EGF and EGF receptor expression. Biochem. Mol. Biol. Int., 30: 1127–1134.
Takekura, N., Yasui, W., Kyo, E., et al., 1991. Effect of tyrosime kinase inhibiter erbstatin on cell growth and growth and growth factor/receptor gene expression in human gastric carcinoma cells. Int. J. Cancer., 47:938–942.
Tarnawski, A., Tanoue, K., Santos, AM., et al., 1995. Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment? Scand J Gastroenterol, 210(Suppl): 9–14.
Tarnawski, A. S., Jones, M. K., 1998. The role of epidermal growth factor (EGF) and its receptor in mucosal protection, adaptation to injury, and ulcer healing: Involvement of EGF-R signal transduction pathways. J. Clin Gastroenterol, 27(Suppl 1): S12–20.
Zhang Hong, Si Jianmin, Wang Kaiming et al., 1998. The expression of EGF and EGFR in chronic atrophic gastritis and its significance in carcinogenesis, Chin. J. Clinical Oncol., 25: 93–95 (in Chinese).
Si Jianmin, Zhang Hong, Wang Kaiming, et al., 1998. Study on the expression of EGG/EGFR and its clinical significance in atrophic gastritis, Chin. J. Digestion, 18: 271–273 (in Chinese).
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Si, Jm., Sun, Lm., Dai, N. et al. Study of sEGF level in chronic atrophic gastritis with either Chinese traditional medicine or western medicine. J. Zheijang Univ.-Sci. A 3, 243–246 (2002). https://doi.org/10.1631/BF03396446
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DOI: https://doi.org/10.1631/BF03396446