Abstract
To study the function of transforming growth factor β1 (TGF-β1) and transforming growth factor-β type II receptor (TGF-βR II) in varying stages of colorectal adenoma during neoplastic transformation, fiftyfive cases of resected colorectal adenomas were examined immunohistochemically. Our results showed that the expression of TGF-β1 ranged from high to low, with the progression of low-grade to high-grade dysplasia of adenomas to carcinoma. And there was significantly different expression of TGF-β1 between moderate and high dysplasia adenomas (P<0.05), but no significantly different expression of TGF-β R II was found among varying stages of adenomas. Our results suggested that the quantities of TGF-β1 secreted by adenoma cells decrease dramatically in moderate to severe dysplasia colorectal adenomas. It is the decreased secretion of TGF-β1, rather than the mutated TGF-βR II that may play an important role in transforming colorectal adenomas to adenocarcinomas.
This is a preview of subscription content, log in via an institution to check access.
References
Brattain, M. G., Markowitz, S.D., Willson, S.K. et al., 1996. The type II transforming growth factor-beta receptor as a tumor-suppressor gene.Curr Opin Oncol.8(1): 49–53.
Coffey, R., Goustin, A., Mangelsdorf-Soderqvist, A. et al., 1987. Transforming growth factor α and β expression in human colon cancer lines: Implications for an autocrine model.Cancer Res,47:4590–4594.
Eskinazi, R., Resibois, A., Svoboda, M. et al., 1998. Expression of Transforming Growth Factor β receptors in normal human colon and sporadic adenocarcinomas.Gastroenterology,114:1211–1220.
Guan, G.X., Zhang, X.F., Yang, F.D. et al., 1998. Expression of Transforming Growth Factor β type Hreceptor in colorectal cancers and precancerous lesions.Chin J Pathol.27(4):306–307.
Laethem, J-L.V., Resibois, A., Adler, M. et al., 1996. Localization of Transforming Growth Factor-β1 precursor and latent TGF-β1 binding protein in colorectal adenomas.Dig Dis Sci.41(9):1741–1748.
Lahm, H., Odartchenko, N., 1993. Role of transforming growth factor β in colorectal cancer.Growth Factors.9: 1–9.
Manning, A. M., Williams, A. C., Game, S. M. et al., 1991. Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor β (TGFβ): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effect of TGF-β.Oncogene. 6: 1471–1476.
Matsushita, M., Matsuzaki, K., Date, M. et al., 1999. Down-regulation of TGF-β receptors in human colorectal cancer: implications for cancer development.Br J Cancer. 80: 194–205.
Muto, T., Bussey, H. J. R., Morson, B. C., 1975. The evolution of cancer of the colon and rectum.Cancer. 36: 2251–2270.
Tsushima, H., Kawata, S., Tamura, S. et al., 1996. High levels of transforming growth factor β1 in patients with colorectal cancer: association with disease progression.Gastroenterology. 110: 375–382.
Zhu, Z. W., Zeng, L. F., Wang, Y. C. et al., 1996. The expressions and changes of TGF-α, βgenes in human cancerous, paracancerous and normal colorectum mucosal tissues.Acta Anatomical Sinica. 27(3): 290–294.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Da, W., Chao, H., Wei, D. et al. Expression of TGF-β1 and TGF-β R II in colorectal adenomas of varying stages. J. Zheijang Univ.-Sci. 2, 107–110 (2001). https://doi.org/10.1631/BF02841187
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1631/BF02841187