Advertisement

Journal of Zhejiang University-SCIENCE B

, Volume 19, Issue 5, pp 409–414 | Cite as

Avian influenza viruses (AIVs) H9N2 are in the course of reassorting into novel AIVs

  • Hui-ping Chang
  • Li Peng
  • Liang Chen
  • Lu-fang Jiang
  • Zhi-jie Zhang
  • Cheng-long XiongEmail author
  • Gen-ming Zhao
  • Yue Chen
  • Qing-wu Jiang
Correspondence

H9N2,行进在新亚型流感病毒的途中

中文概要

目的

分析H9N2 禽流感病毒通过基因重配形成H7N9 和H10N8 人间禽流感病毒的进程,探讨作为供体 的禽流感病毒H9N2 在当前中国的主要分布及其 内部6 个基因节段的进化关系。

创新点

人间禽流感病毒H7N9 和H10N8 共起源于H9N2 禽流感病毒早已成为共识,但共起源的时间节 点、作为供体的禽流感病毒H9N2 在当前中国的 分布及其内部6 个基因节段的进化关系鲜有论 及。2014 年,H5N6 禽流感被多次报道造成人类 感染。研究表明,H5N6 禽流感具有复杂的重配 来源,H9N2 正是其一,加之H7N9 第五波流行 的严峻形势,亟需明确H9N2 禽流感病毒通过基 因重配形成新亚型的能力以及它在我国的当前 主要分布。

方法

从流感病毒公共数据库下载基因序列,评估查找 适当的碱基替代模型,通过进化树查看与H7N9、 H10N8 及H5N6 具有高度相似性的H9N2 病毒的 分布地区以及它们在内部6 个基因节段上的进化 关系,同时通过碱基替代速率的计算追溯最近共 同祖先(tMRCA)及其分歧时间。

结论

人间禽流感病毒H7N9 与H10N8 均在2012 年之 前形成,短期内通过碱基替代与基因重配形成了 两种可感染人类的禽流感病毒,证实了H9N2 通 过重配形成新亚型的高效性。作为重配供体的 H9N2 至今仍广布于华东、华南及东南亚。其内 部基因节段的重配复杂,发生在亚型内部的重配 以及通过重配形成新的病毒亚型的风险都很高, 需在禽畜中加强流感病毒的流行动态监测,特别 是那些一向被忽视的编码内部蛋白的基因组节 段。

关键词

禽流感病毒 H9N2 H10N8 H7N9 中国 共 起源 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Supplementary material

11585_2018_10_MOESM1_ESM.pdf (257 kb)
Avian influenza viruses (AIVs) H9N2 are in the course of reassorting into novel AIVs

References

  1. Bi Y, Chen Q, Wang Q, et al., 2016. Genesis, evolution and prevalence of H5N6 avian influenza viruses in China. Cell Host Microbe, 20(6):810–821. https://doi.org/10.1016/j.chom.2016.10.022 CrossRefPubMedGoogle Scholar
  2. Chen H, Yuan H, Gao R, et al., 2014. Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study. Lancet, 383(9918):714–721. https://doi.org/10.1016/S0140-6736(14)60111-2 CrossRefPubMedGoogle Scholar
  3. Chen L, Lin X, Tian J, et al., 2017. Diversity, evolution and population dynamics of avian influenza viruses circulating in the live poultry markets in China. Virology, 505: 33–41. https://doi.org/10.1016/j.virol.2017.02.009 CrossRefPubMedGoogle Scholar
  4. Chen Y, Liang W, Yang S, et al., 2013. Human infections with the emerging avian influenza a H7N9 virus from wet market poultry: clinical analysis and characterization of viral genome. Lancet, 381(9881):1916–1925. https://doi.org/10.1016/S0140-6736(13)60903-4 CrossRefPubMedGoogle Scholar
  5. Cheng X, Liu J, He J, et al., 2002. Virological and serological surveys for H9N2 subtype of influenza a virus in chickens and men in Shenzhen city. Chin J Exp Clin Virol, 16(4): 319–321 (in Chinese).Google Scholar
  6. Cui L, Liu D, Shi W, et al., 2014. Dynamic reassortments and genetic heterogeneity of the human-infecting influenza a (H7N9) virus. Nat Commun, 5:3142. https://doi.org/10.1038/ncomms4142 CrossRefPubMedGoogle Scholar
  7. Dong G, Xu C, Wang C, et al., 2011. Reassortant H9N2 influenza viruses containing H5N1-like PB1 genes isolated from black-billed magpies in southern China. PLoS ONE, 6(9):e25808. https://doi.org/10.1371/journal.pone.0025808 CrossRefPubMedPubMedCentralGoogle Scholar
  8. Du Y, Chen M, Yang J, et al., 2017. Molecular evolution and emergence of H5N6 avian influenza virus in central China. J Virol, 91(12):e00143–17. https://doi.org/10.1128/JVI.00143-17 CrossRefPubMedPubMedCentralGoogle Scholar
  9. Gu M, Liu WB, Cao JP, et al., 2010. Genome sequencing and genetic analysis of a natural reassortant H5N1 subtype avian influenza virus possessing H9N2 internal genes. Chin J Virol, 26(4):298–304 (in Chinese).Google Scholar
  10. Gu M, Xu L, Wang X, et al., 2017. Current situation of H9N2 subtype avian influenza in China. Vet Res, 48(1):49. https://doi.org/10.1186/s13567-017-0453-2 CrossRefPubMedPubMedCentralGoogle Scholar
  11. Iuliano AD, Jang Y, Jones J, et al., 2017. Increase in human infections with avian influenza A (H7N9) virus during the fifth epidemic—China, October 2016–February 2017. Morb Mortal Wkly Rep, 66(9):254–255. https://doi.org/10.15585/mmwr.mm6609e2 CrossRefGoogle Scholar
  12. Jiang W, Liu S, Hou G, et al., 2012. Chinese and global distribution of H9 subtype avian influenza viruses. PLoS ONE, 7(12):e52671. https://doi.org/10.1371/journal.pone.0052671 CrossRefPubMedPubMedCentralGoogle Scholar
  13. Jiao P, Cui J, Song Y, et al., 2016. New reassortant H5N6 highly pathogenic avian influenza viruses in Southern China, 2014. Front Microbiol, 7:754. https://doi.org/10.3389/fmicb.2016.00754 PubMedPubMedCentralGoogle Scholar
  14. Kang Y, Liu L, Feng M, et al., 2017. Highly pathogenic H5N6 influenza a viruses recovered from wild birds in Guangdong, southern China, 2014–2015. Sci Rep, 7:44410. https://doi.org/10.1038/srep44410 CrossRefPubMedPubMedCentralGoogle Scholar
  15. Li Q, Zhou L, Zhou M, et al., 2014. Epidemiology of human infections with avian influenza A (H7N9) virus in China. New Engl J Med, 370(6):520–532. https://doi.org/10.1056/NEJMoa1304617 CrossRefPubMedGoogle Scholar
  16. Liu M, Li X, Yuan H, et al., 2015. Genetic diversity of avian influenza A (H10N8) virus in live poultry markets and its association with human infections in China. Sci Rep, 5: 7632. https://dx.doi.org/10.1038/srep07632 CrossRefPubMedPubMedCentralGoogle Scholar
  17. Padidam M, Sawyer S, Fauquet C, 1999. Possible emergence of new geminiviruses by frequent recombination. Virol, 265(2):218–225. https://doi.org/10.1006/viro.1999.0056 CrossRefGoogle Scholar
  18. Tang Q, Shao M, Xu L, 2017. China is closely monitoring an increase in infection with avian influenza A (H7N9) virus. Biosci Trends, 11(1):122–124. https://doi.org/10.5582/bst.2017.01041 CrossRefPubMedGoogle Scholar
  19. WHO (World Health Organization), 2017. Influenza at the human-animal interface summary and assessment, 21 April to 16 May 2017. http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_05_16_2017.pdf?ua=1 [Accessed on May 25, 2017].Google Scholar
  20. Zhang Z, Li R, Jiang L, et al., 2016. The complexity of human infected AIV H5N6 isolated from China. BMC Infect Dis, 16:600. https://doi.org/10.1186/s12879-016-1932-1 CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Zhejiang University and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Life SciencesHenan Institute of EducationZhengzhouChina
  2. 2.Shanghai Key Laboratory of Meteorology and HealthShanghaiChina
  3. 3.Department of Public Health Microbiology, School of Public HealthFudan UniversityShanghaiChina
  4. 4.Key Laboratory of Public Health Safety, Ministry of EducationFudan UniversityShanghaiChina
  5. 5.Department of Epidemiology, School of Public HealthFudan UniversityShanghaiChina
  6. 6.School of Epidemiology and Public Health, Faculty of MedicineUniversity of OttawaOttawa, OntarioCanada

Personalised recommendations