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Journal of Zhejiang University SCIENCE B

, Volume 14, Issue 11, pp 1033–1040 | Cite as

Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy

  • Fang LiuEmail author
  • Min Wu
  • Yan-huan Feng
  • Hui Zhong
  • Tian-lei Cui
  • You-qun Huang
  • Ya-ping Liang
  • Yong-shu Diao
  • Li Zang
  • Ling Li
  • Jing Zang
  • Hong-yu Qiu
  • Song-min Huang
  • Ping FuEmail author
Article

Abstract

The aim of this study was to understand the characteristics of blood pressure (BP) variability in subjects with diabetic nephropathy (DN), and identify the probable predictors affecting BP variability. Fifty-one chronic kidney disease (CKD)-hypertensive patients without diabetes (NDN group) and sixty type 2 diabetic patients with overt DN (DN group) were enrolled in this study. The values of short-term BP variability were obtained from 24 h ambulatory BP monitoring (ABPM). Variance analysis or nonparametric analysis revealed that 24-h systolic BP variability and nighttime systolic BP variability of the DN group were significantly higher than those of the NDN group [(12.23±3.66) vs. (10.74±3.83) mmHg, P<0.05; (11.23±4.82) vs. (9.48±3.69) mmHg, P<0.05]. Then the patients of the DN group were divided into two groups according to glycated hemoglobin (HbA1c) level: Group A (HbA1c<7%) and Group B (HbA1c≥7%), and the t-test showed that patients in Group B had larger 24-h diastolic, daytime diastolic, and nighttime systolic/diastolic BP variability compared with Group A. In the DN group, partial correlation analysis revealed that HbA1c exhibited a strong association with 24-h diastolic, daytime diastolic, nighttime systolic and diastolic BP variability (P<0.001, P<0.001, P<0.05, and P<0.001, respectively). Taken together, larger short-term BP variability was detected in hypertensive type 2 diabetic patients with overt nephropathy and renal insufficiency. It may imply that the optimal BP variability level could benefit from a better glycaemic control.

Key words

Short-term blood pressure variability Diabetic nephropathy Glycated hemoglobin (HbA1c) Hypertension Glycaemic control 

CLC number

R543 

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Copyright information

© Zhejiang University and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Fang Liu
    • 1
    Email author
  • Min Wu
    • 1
  • Yan-huan Feng
    • 1
  • Hui Zhong
    • 1
  • Tian-lei Cui
    • 1
  • You-qun Huang
    • 1
  • Ya-ping Liang
    • 1
  • Yong-shu Diao
    • 1
  • Li Zang
    • 1
  • Ling Li
    • 1
  • Jing Zang
    • 1
  • Hong-yu Qiu
    • 1
  • Song-min Huang
    • 1
  • Ping Fu
    • 1
    Email author
  1. 1.Division of NephrologyWest China Hospital of Sichuan UniversityChengduChina

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