Journal of Zhejiang University SCIENCE B

, Volume 13, Issue 9, pp 745–750

Topical imiquimod treatment of cutaneous vascular disorders in pediatric patients: clinical evaluation on the efficacy and safety


DOI: 10.1631/jzus.B1200120

Cite this article as:
Mao, X., Wang, J. & Yan, J. J. Zhejiang Univ. Sci. B (2012) 13: 745. doi:10.1631/jzus.B1200120



To evaluate the clinical effect of topical imiquimod treatment on cutaneous vascular disorders in pediatric patients.


A retrospective investigation was conducted in 25 pediatric patients with cutaneous vascular disorders, including 19 infantile hemangiomas (IHs) (12 superficial/7 mixed type), 5 nevus flammeus (NF), and 1 pyogenic granuloma (PG). Imiquimod 5% cream was applied every other day for 4 to 16 weeks (average 9.6 weeks).


Of the 19 IHs treated, an overall efficacy of 52.6% was achieved, with a clinical resolution rate of 15.8%, excellent rate of 26.3%, and moderate rate of 10.5%. The superficial type responded the best at 66.7%, while the mixed type showed only 28.6% effectiveness, which was predominantly from their superficial parts. No obvious response was noted in the 5 patients with NF. Side effects were observed in 78.9% of the patients, mostly mild to moderate local irritations and occasionally severe reactions such as thick crusting and ulceration. Systemic side events were observed in 4 IH patients including fever and digestive tract reactions. No recurrence was observed during the follow-up examination.


Topical imiquimod could be an alternative option for the treatment of uncomplicated superficial IHs with satisfactory tolerability.

Key words

Infantile hemangioma (IH) Nevus flammeus (NF) Imiquimod Treatment 

CLC number


Copyright information

© Zhejiang University and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Dermatology, the Second Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina

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