Biological control of aflatoxin contamination of crops
- 506 Downloads
Aflatoxins produced primarily by two closely related fungi, Aspergillus flavus and Aspergillus parasiticus, are mutagenic and carcinogenic in animals and humans. Of many approaches investigated to manage aflatoxin contamination, biological control method has shown great promise. Numerous organisms, including bacteria, yeasts and nontoxigenic fungal strains of A. flavus and A. parasiticus, have been tested for their ability in controlling aflatoxin contamination. Great successes in reducing aflatoxin contamination have been achieved by application of nontoxigenic strains of A. flavus and A. parasiticus in fields of cotton, peanut, maize and pistachio. The nontoxigenic strains applied to soil occupy the same niches as the natural occurring toxigenic strains. They, therefore, are capable of competing and displacing toxigenic strains. In this paper, we review recent development in biological control of aflatoxin contamination.
Key wordsAflatoxin Aspergillus Biocontrol Food safety
Unable to display preview. Download preview PDF.
- Brown, R.L., Cotty, P.J., Cleveland, T.E., 1991. Reduction in aflatoxin content of maize by atoxigenic strains of Aspergillus flavus. J. Food Prot., 54(8):623–626.Google Scholar
- Cardwell, K.F., Henry, S.H., 2004. Risk of exposure to and mitigation of effect of aflatoxin on human health: a West African example. J. Toxicol. Toxin Rev., 23(2&3):217–247.Google Scholar
- Chang, P.K., 2003. The Aspergillus parasiticus protein aflJ interacts with the aflatoxin pathway-specific regulator aflR. Mol. Gen. Genomics, 268(6):711–719.Google Scholar
- Dorner, J.W., 2004. Biological control of aflatoxin contamination of crops. J. Toxicol. Toxin Rev., 23(2&3):425–450.Google Scholar
- Dorner, J.W., Cole, R.J., Blankenship, P.D., 1992. Use of a biocompetitive agent to control preharvest aflatoxin in drought stressed peanuts. J. Food Prot., 55(11):888–892.Google Scholar
- Ehrlich, K.C., Cotty, P.J., 2004. An isolate Aspergillus flavus used to reduce aflatoxin contamination in cottonseed has a defective polyketide synthase gene. J. Microbiol. Biotehnol., 65(4):473–478.Google Scholar
- Garber, N., Cotty, P.J., 2006. Timing of Herbicide Applications may Influence Efficacy of Aflatoxin Biocontrol. Beltwide Cotton Conferences, San Antonio, TX, USA p.11.Google Scholar
- van Egmond, H.P., Jonker, M.A., 2004. Worldwide regulations on aflatoxins—the situation in 2002. J. Toxicol. Toxin Rev., 23(2&3):273–293.Google Scholar
- Yin, Y., Lou, T., Jiang, J., Yan, L., Michailides, T.J., Ma, Z., 2008. Molecular characterization of toxigenic and atoxigenic Aspergillus flavus isolates collected from soil in various agroecosystems in China. Food Microbiol., manuscript sumbitted for publication.Google Scholar
- Yu, J., Chang, P.K., Ehrlich, K.C., Cary, J.W., Bhatnagar, D., Cleveland, T.E., Payne, G.A., Linz, J.E., Woloshuk, C.P., Bennett, J.W., 2004. Clustered pathway genes in aflatoxin biosynthesis. Appl. Environ. Microbiol., 70(3):1253–1262. [doi:10.1128/AEM.70.3.1253-1262.2004]PubMedCrossRefGoogle Scholar