Journal of Zhejiang University SCIENCE B

, Volume 9, Issue 2, pp 85–89

BRCA1/2 associated hereditary breast cancer


DOI: 10.1631/jzus.B0710617

Cite this article as:
Teng, L., Zheng, Y. & Wang, H. J. Zhejiang Univ. Sci. B (2008) 9: 85. doi:10.1631/jzus.B0710617


Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial; further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.

Key words

BRCA1 BRCA2 Hereditary breast cancer 

Document code

CLC number


Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Cancer Center, the First Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina

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