Journal of Zhejiang University-SCIENCE A

, Volume 4, Issue 5, pp 602–606

Quality of life and cost-effectiveness of combined therapy for reflux esophagitis

  • Si Jian-min
  • Wang Liang-jing
  • Chen Shu-jie
  • Zhao Lan
  • Dai Ning
Medicine

Abstract

Objective: To evaluate clinical, Quality of Life (QoL) and medical cost outcomes in patients with symptomatic reflux esophagitis (RE) receiving different “triple combination therapy”. Methods: A multicenter medical effectiveness trial conducted in 10 hospitals of 5 regions in Zhejiang Province. 248 patient-volunteers were assigned to 8 weeks of “triple combination therapy” with Lansoprazole plus Cisapride and Sucralfate or Ranitidine plus Cisapride and Sucralfate. Main outcomes assessment included symptoms scale scores, RE severity, QoL at baseline and 8 weeks. Medical cost data were collected with cost analysis questionnaire. Results: (1) More Lansoprazole group patients noted RE symptoms resolution than Ranitidine group (92.3% vs 78.4%,P<0.01). There was no striking difference between two groups in RE healing rate (90.8% vs 82.9%,P>0.05). (2) RE significantly impaired QoL of patients (P<0.001). Compared with Ranitidine group, QoL in Lansoprazole group had significant improvement (rate of “good” QoL 64.5% vs 45.6%,P<0.01). (3) There was close correlation between symptomic effectiveness and QoL rating scale in both the Lansoprazole and Ranitidine group (P<0.01,r=0.235 and 0.353 respectively). There were no statistical difference of medical cost between the two groups (P>0. 05). Conclusion: RE significantly impaired QoL of patients. “Triple combination therapies” can significantly improve RE symptoms and QoL. Lansoprazole combination therapy was more cost-effective than Ranitidine combination group.

Key words

Reflux esophagitis (RE) Quality of life Cost-effectiveness 

Document code

CLC number

R571 

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Copyright information

© Zhejiang University Press 2003

Authors and Affiliations

  • Si Jian-min
    • 1
  • Wang Liang-jing
    • 1
  • Chen Shu-jie
    • 1
  • Zhao Lan
    • 1
  • Dai Ning
    • 1
  1. 1.Sir Run Run Shaw Hospital, College of MedicineZhejiang UniversityHangzhouChina

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