, Volume 2, Issue 3, pp 447–464

The use of the R6 transgenic mouse models of Huntington’s disease in attempts to develop novel therapeutic strategies



Huntington’s disease (HD) is a genetic neurodegenerative disorder. Since identification of the disease-causing gene in 1993, a number of genetically modified animal models of HD have been generated. The first transgenic mouse models, R6/1 and R6/2 lines, were established 8 years ago. The R6/2 mice have been the best characterized and the most widely used model to study pathogenesis of HD and therapeutic interventions. In the present review, we especially focus on the characteristics of R6 transgenic mouse models and, in greater detail, describe the different therapeutic strategies that have been tested in these mice. We also, at the end, critically assess the relevance of the HD mouse models compared with the human disease and discuss how they can be best used in the future.

Key Words

Huntington’s disease therapy transgenic mice R6/2 neurodegenerative diseases 

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc 2005

Authors and Affiliations

  1. 1.Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical ScienceBMC A10LundSweden

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