, Volume 1, Issue 1, pp 36–45

Neuroprotection for ischemic stroke: Two decades of success and failure

  • Yu Dennis Cheng
  • Lama Al-Khoury
  • Justin A. Zivin


Alteplase (rt-PA) is the first therapy successfully developed for acute stroke therapy. The success of rt-PA spurred development of new avenues for acute stroke management. For the last two decades, a great deal of attention has been paid to neuroprotective therapies. Initial preclinical studies demonstrated numerous drugs are effective for treating acute stroke in animal models; however, subsequent clinical trials have been frustrating, and none of the agents has proven effective. The various outcomes of preclinical and clinical trials have been the subject of much discussion. In this article, we review some key neuroprotective trials and the possible reasons for their failures. By identifying the discrepancies between preclinical studies and clinical trials, we may be able to set guidelines for future effective trials.

Key Words

Neuroprotection trials glutamate antagonists anti-inflammatory agents ion channel blocks free radical scavengers neurotrophic factors neural stem cells 


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Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc 2004

Authors and Affiliations

  • Yu Dennis Cheng
    • 1
  • Lama Al-Khoury
    • 1
  • Justin A. Zivin
    • 1
    • 2
  1. 1.Stroke CenterUniversity of California School of Medicine, and University of California San DiegoLa Jolla
  2. 2.Department of NeurosciencesUniversity of California San DiegoLa Jolla

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