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Theragnostic liposomes for the diagnosis and treatment of tuberculosis

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Abstract

The indiscriminate use of antibiotics has generated super bacteria resistant to many conventional drugs. Tuberculosis is caused by the bacterium Mycobacterium tuberculosis, the use of conventional treatments for this disease generates significant damage to the liver and kidney functions of patients, which is why treatments are required that allow early diagnosis and selectivity for Pathogenic bacteria. In this work, a drug currently used for the treatment of tuberculosis (rifampicin) and silver nanoparticles as luminescent biomarkers are being encapsulated, and estimated by means of UV–VIS, FTIR, and DLS techniques for the design of theragnostic liposomes. The results show that this type of liposomes have important characteristics to be used as elements of early diagnosis in addition to its possible therapeutic use.

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The authors declare that the all data supporting the findings of this study are available within the article.

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Acknowledgments

A financial support from the Secretary of Investigation and Postgraduate Study of Instituto Politécnico Nacional (SIP IPN Mexico), and the National Council of Science and Technology of Mexico (CONACYT) for Postdoc and PhD grants greatly appreciated. The authors are grateful to Dr. Lopatko Konstantin from National University of Life and Environmental Sciences of Ukraine for providing the silver nanoparticles.

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Authors and Affiliations

  1. UPIITA – Instituto Politécnico Nacional, 07320, Mexico City, Mexico

    Rebeca Jiménez-Rodríguez, Janna Douda, I. I. Mota-Díaz & I. C. Romera-Ibarra

  2. UNAM - Posgrado de la Facultad de Estudios Superiores Cuautitlán, 54740, Cuautitlan Izcalli, Estado de Mexico, Mexico

    I. I. Mota-Díaz

  3. ENCB-Instituto Politécnico Nacional, 11340, Mexico City, Mexico

    Julieta Luna-Herrera

  4. ESFM – Instituto Politécnico Nacional, 07738, Mexico City, Mexico

    J. L. Casas-Espínola

Authors
  1. Rebeca Jiménez-Rodríguez
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  2. Janna Douda
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  3. I. I. Mota-Díaz
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  4. Julieta Luna-Herrera
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  5. I. C. Romera-Ibarra
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  6. J. L. Casas-Espínola
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Correspondence to Rebeca Jiménez-Rodríguez.

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Jiménez-Rodríguez, R., Douda, J., Mota-Díaz, I.I. et al. Theragnostic liposomes for the diagnosis and treatment of tuberculosis. MRS Advances 8, 67–70 (2023). https://doi.org/10.1557/s43580-023-00496-3

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  • DOI: https://doi.org/10.1557/s43580-023-00496-3

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