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Development of deep eutectic solvent systems and their formulation: Assessment of solubilization potential on poorly water-soluble drugs

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Abstract

Modern strategies to deliver drugs efficiently via less toxic non-aqueous carriers like deep eutectic solvents (DES) has grown tremendously. Herein, we develop several synthetic and natural DES to improve solubility of poorly soluble drug, docetaxel (DTX). Menthol:thymol-based natural DES showed 1500-folds higher solubility for DTX than that in water. FTIR-spectroscopy confirmed reduced crystallinity and stable encapsulation of DTX in DES through formation of hydrogen-bond. DTX-DES was developed further into self-emulsified formulation that upon dilution formed nanostructured globules (< 200 nm) and released 20-folds higher DTX than pure drug thereby highlighting the potential of DES for designing formulations of poorly soluble drugs.

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Acknowledgments

The authors would like to acknowledge the support of Massachusetts Life Sciences Center (MLSC) for UPLC/MS equipment grant.

Funding

This work was funded by Massachusetts Life Sciences Center (MLSC), Boston, MA.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, Tufts University, Medford, MA, 02155, USA

    Brijesh M. Shah, Rachel E. Owyeung & Sameer Sonkusale

  2. Nano Lab, Tufts University, Medford, MA, 02155, USA

    Brijesh M. Shah, Rachel E. Owyeung & Sameer Sonkusale

  3. Anodyne Nanotech, Inc., Boston, MA, 02118, USA

    Brijesh M. Shah

Authors
  1. Brijesh M. Shah
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  2. Rachel E. Owyeung
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  3. Sameer Sonkusale
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Contributions

All authors contributed to the study conception. BS contributed to study design. BS and RO contributed to experimentation and analysis. BS contributed to writing original draft of the manuscript. SS contributed to supervision, review, and editing.

Corresponding author

Correspondence to Sameer Sonkusale.

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Shah, B.M., Owyeung, R.E. & Sonkusale, S. Development of deep eutectic solvent systems and their formulation: Assessment of solubilization potential on poorly water-soluble drugs. MRS Communications (2024). https://doi.org/10.1557/s43579-024-00552-5

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  • DOI: https://doi.org/10.1557/s43579-024-00552-5

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