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Fabrication and characterization of biomimetic injectable HA/GT-OSA composites for bone regeneration

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Abstract

To address the issue of limited bone repair efficacy, a novel biomimetic HA/GT-OSA composite was synthesized through crosslinking gelatin (GT) with oxidized sodium alginate (OSA) for encapsulating hydroxyapatite (HA). The physicochemical properties of the composite were assessed using SEM, XRD, and FT-IR analyses. The biodegradability and biocompatibility of the HA/GT-OSA were confirmed via simulated body fluid (SBF) degradation testing and toxicity evaluation. Moreover, the HA/GT-OSA composites showed excellent bone regeneration performance in the SD rats intracranial bone repair, highlighting their immense potential for treating irregular bone defects and facilitating minimally invasive surgical implantation.

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Funding

The authors acknowledge funding support from the Yanglei Academician Expert Workstation of Yunnan Province (202205AF15025), Yunnan Innovation Team of Graphene Mechanism Research and Application Industrialization (202305AS350017), Graphene Application and Engineering Research Center of Education Department of Yunnan Province (KKPP202351001).

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Author notes

  1. Jie Yu, Qiang Zhao, Ting Xiao have contributed equally to this work.

Authors and Affiliations

  1. Kunming University of Science and Technology, Yunnan, 650093, China

    Jie Yu, Han-Wu Liu, Xi-Liang Chen, Jia He & Ting-Ting Yan

  2. Department of Stomatology, 920 Hospital of Joint Logistics Support Force, PLA, Kunming, 650032, China

    Qiang Zhao

  3. School of Dental Medicine, Changsha Stomatological Hospital, Hunan University of Chinese Medicine, Changsha, Hunan, China

    Ting Xiao

Authors
  1. Jie Yu
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  2. Qiang Zhao
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  3. Ting Xiao
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  4. Han-Wu Liu
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  5. Xi-Liang Chen
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  6. Jia He
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  7. Ting-Ting Yan
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Contributions

JY: Conceptualization, Data curation, Writing—original draft, Writing—review and editing. QZ: Data curation. TX: Data curation. HL: Conceptualization, Data Curation., XC: Conceptualization, Formal analysis, Writing—review, and editing, JH: Conceptualization, Formal analysis, Writing—review, and editing. TY: Funding acquisition, Conceptualization, Formal analysis, Writing—review and editing.

Corresponding authors

Correspondence to Jia He or Ting-Ting Yan.

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Conflicts of interest

The corresponding author declares on behalf of all authors that there are no known conflicts of interest and competing interests.

Ethical approval

All animal experiments and research procedures are licensed and approved by the Science and Technology Bureau of Kunming, Yunnan Province, China (license number (SYXK-K2018-0008)), in line with human moral and ethical standards and international practices, and no adverse events have occurred.

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Yu, J., Zhao, Q., Xiao, T. et al. Fabrication and characterization of biomimetic injectable HA/GT-OSA composites for bone regeneration. MRS Communications (2024). https://doi.org/10.1557/s43579-024-00525-8

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  • DOI: https://doi.org/10.1557/s43579-024-00525-8

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