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Bone tissue engineering scaffolds based on polycaprolactone coated with gelatin-poly (vinylalcohol)/MgSO4: Fabrication, morphology, and properties

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Abstract

Both mechanical and biological properties of Polycaprolactone (PCL)-based scaffolds coated with gelatin-PVA/MgSO4 were studied. The scaffolds were prepared using salt leaching technique. The scaffold functionality and morphology were investigated using scanning electron microscopy and Fourier transform infrared (FTIR) spectra. The porous scaffolds had pore sizes in the range 80–240 nm. The PCL, PVA, Gelatin and MgSO4 components were confirmed by FTIR spectra. Magnesium sulfate addition mainly reduced tensile strength and cell viability, while it increased the degradation rate. On the other hand, the swelling percentage was not significantly affected.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgments

The authors would like to thank Science Classroom in University Affiliated School (SCiUS). This project was supported by a grant from the Ministry of Higher Education, Science, Research and Innovation.

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Authors and Affiliations

  1. Faculty of Science and Industrial Technology, Prince of Songkla University, Surat Thani Campus, Surat Thani, 84000, Thailand

    Atsadaporn Thangprasert, Suchaj Keatipimol & Anchidtha Pachano

  2. Faculty of Technology and Environment, Prince of Songkla University, Phuket Campus, Kathu, Phuket, 83120, Thailand

    Pakorn Pasitsuparoad

  3. Division of Biomedical Science and Biomedical Engineering, Prince of Songkla University, Hatyai Campus, Hatyai, Songkhla, 90110, Thailand

    Jirut Meesane

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  1. Pakorn Pasitsuparoad
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  2. Atsadaporn Thangprasert
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Correspondence to Atsadaporn Thangprasert.

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Pasitsuparoad, P., Thangprasert, A., Keatipimol, S. et al. Bone tissue engineering scaffolds based on polycaprolactone coated with gelatin-poly (vinylalcohol)/MgSO4: Fabrication, morphology, and properties. MRS Communications 13, 21–26 (2023). https://doi.org/10.1557/s43579-022-00306-1

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  • DOI: https://doi.org/10.1557/s43579-022-00306-1

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