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Digital light processing-based 3D printing of polytetrafluoroethylene solid microneedle arrays

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Abstract

This study evaluated the structural and skin penetration properties of solid microneedle arrays made by digital light processing-based 3D printing of polytetrafluoroethylene. Confocal laser scanning microscopy and scanning electron microscopy revealed that the microneedles exhibited uniform heights. Raman spectroscopy, X-ray photoelectron spectroscopy, nanoindentation, and contact angle results indicated that the composition, carbon–fluorine bonding, reduced elastic modulus, and contact angle values of the 3D-printed polytetrafluoroethylene corresponded with those of bulk polytetrafluoroethylene, respectively. Methyl blue was used to evaluate the human skin penetration functionality of the microneedle array. Our results indicate that digital light processing is appropriate for manufacturing polytetrafluoroethylene medical devices.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgments

The authors would like to acknowledge the assistance of Bob Fidler and Paul Simutis with DataPhysics Instruments USA Corp. for their assistance with optical contact angle measurements and data interpretation. Funding was provided through the "Cares Act" with programmatic oversight from the Medical Research and Development Command, Military Infectious Diseases Research Program. Support from MTEC is also acknowledged; MTEC is a 501(c)(3) biomedical technology consortium collaborating with multiple government agencies under a 10-year renewable Other Transactional Agreement with the U.S. Army Medical Research and Development Command. MTEC is managed by Advanced Technology International.

Author information

Authors and Affiliations

  1. North Carolina State University, Raleigh, NC, USA

    Roger Sachan

  2. Department of Biomedical Engineering, North Carolina State University, Box 7115, Raleigh, NC, 27695-7115, USA

    Alexander K. Nguyen & Roger J. Narayan

  3. Department of Dermatology, Duke University Medical Center, Durham, NC, USA

    Junqi Lu & Jennifer Y. Zhang

  4. Division of Plastic, Maxillofacial and Oral Surgery, Duke University Medical Center, Durham, NC, USA

    Detlev Erdmann

Authors
  1. Roger Sachan
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  2. Alexander K. Nguyen
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  3. Junqi Lu
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  4. Detlev Erdmann
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  5. Jennifer Y. Zhang
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  6. Roger J. Narayan
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Corresponding author

Correspondence to Roger J. Narayan.

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Sachan, R., Nguyen, A.K., Lu, J. et al. Digital light processing-based 3D printing of polytetrafluoroethylene solid microneedle arrays. MRS Communications 11, 896–901 (2021). https://doi.org/10.1557/s43579-021-00121-0

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