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Fabrication and characterization of nanocomposite hydrogel based N-succinyl chitosan/oxidized tragacanth gum/silver nanoparticles for biomedical materials

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Abstract

Nowadays, there is significant interest in hydrogels that have injectable, self-healing, and antibacterial properties. These features make them highly desirable for use in wound dressings. In this study, a class of biocompatible nanocomposite hydrogels was designed based on oxidized tragacanth gum (OTG), N-succinyl chitosan (NSC), and silver nanoparticles (AgNPs) for biomedical applications. To obtain the nanocomposite hydrogels containing different AgNP content, we utilized silver nanoparticles at concentrations of 4, 6, and 8 mg/mL. The OTG/NSC/Ag hydrogel demonstrated superior mechanical properties compared with the OTG/NSC hydrogel without AgNP. The hydrogels also exhibited rapid gelation ( < 60 s), sufficient swelling capacity, and outstanding injectability. The hemolysis and antibacterial tests demonstrated that the produced hydrogels possess non-hemolytic and antibacterial properties. In addition, the hydrogels loaded with AgNPs exhibited low toxicity to fibroblast cells (L929), thus demonstrating acceptable biocompatibility. These findings indicated that the prepared hydrogels could be utilized as novel wound dressing materials.

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Acknowledgments

The authors thank Dr. Mohammad Taghi Razavi Tousi for his kind assistance with hemolytic testing.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Textile Engineering, Faculty of Engineering, University of Guilan, Rasht, Iran

    Atefeh Afroozan Bazghaleh & Mojtaba Akbari Dogolsar

  2. Department of Biomaterials, Faculty of Science, Iran Polymer and Petrochemical Institute, Tehran, Iran

    Jalal Barzin

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  1. Atefeh Afroozan Bazghaleh
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  2. Mojtaba Akbari Dogolsar
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  3. Jalal Barzin
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Contributions

AAB and MAD conceived and planned the experiments. AAB carried out the experiments. AAB took the lead in writing the manuscript. MAD and JB helped supervise the project. All authors provided critical feedback and helped shape the research and analysis.

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Correspondence to Mojtaba Akbari Dogolsar.

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Bazghaleh, A.A., Dogolsar, M.A. & Barzin, J. Fabrication and characterization of nanocomposite hydrogel based N-succinyl chitosan/oxidized tragacanth gum/silver nanoparticles for biomedical materials. Journal of Materials Research (2024). https://doi.org/10.1557/s43578-024-01437-y

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