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Nanocomposites Fe2O3/PNR loaded partially reduced rGO/GCE as an electrochemical probe for selective determination of uric acid and dopamine

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Abstract

In the paper, a high-performance electrode was reported for the determination of uric acid (UA) and dopamine (DA) by loading nanocomposites Fe2O3/poly-neutral red (PNR)/partially reduced graphene oxide (rGO) on glassy carbon electrode (GCE). The nanocomposites Fe2O3/PNR/rGO were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectrometer (FTIR), and electrochemical impedance spectroscopy (EIS). Under the optimized condition, the peak currents of UA and DA showed good linear relationships with their concentrations in the range of 1 × 10–6 to 1 × 10–3 mol L−1 and 3 × 10–7 to 9 × 10–5 mol L−1, respectively. The recovery rates were 93.0–102.0% and 99.2–104.6% for detecting DA from medical injections and human specimens, including urine and serum, respectively, 95.5–105.0% for UA from urine and serum samples. Obviously, this Fe2O3/PNR/rGO/GCE is expected to be used in production quality control and clinical test.

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Acknowledgments

This work was supported by the Liaoning Province Department of Education Fund (JYTJCZR2020069).

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Authors and Affiliations

  1. College of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, China

    Xinxin Qiao, Ruihan Bian, Shu Li, Jialei Zhu, Fuqin Wang & Chang Liu

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  1. Xinxin Qiao
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  2. Ruihan Bian
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  3. Shu Li
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  4. Jialei Zhu
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  5. Fuqin Wang
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  6. Chang Liu
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Contributions

Xinxin Qiao performed to the experiment and wrote the manuscript; Shu Li contributed to the data analyses; Jialei Zhu contributed to the manuscript preparation; Fuqin Wang contributed to the experiment; and Chang Liu helped perform the analysis with constructive discussions.

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Correspondence to Chang Liu.

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Qiao, X., Bian, R., Li, S. et al. Nanocomposites Fe2O3/PNR loaded partially reduced rGO/GCE as an electrochemical probe for selective determination of uric acid and dopamine. Journal of Materials Research (2024). https://doi.org/10.1557/s43578-024-01411-8

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