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Effects of heat treatment of various pure metals on osteoblast cell activity

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  • FOCUS ISSUE: Advances in Titanium Bio-Implants
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Abstract

Titanium (Ti) alloys can be applied for biomaterials of artificial bone and bone repair. However, Ti alloys are bioinert materials, i.e., they have low bone formation ability. The heat treatments of Ti alloys promote bone formation ability, but the mechanism for the promotion has not been well understood. The effects of heat treatment of titanium, zirconium, niobium, and tantalum metals on the behavior of MC3T3-E1 osteoblast-like cells during culturing in vitro were examined. The specimens were heated at temperatures from 400 to 800 °C in the air for oxidation. The oxidation of the metal surface by the heat treatment changed its surface to hydrophilic and increased the surface roughness. Cell extension and proliferation were influenced not by metal species and their oxides but by surface roughness and wettability. The hydrophilicity and smooth surface improved cell extension and cell proliferation.

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Acknowledgments

This work was partly supported by the education and research funds of the Light Metal Educational Foundation, Inc. This work was also supported in part by JKA and its promotion funds (27-165) from Auto Race. This work was partly supported by the joint usage/research program of the Institute of Materials and Systems for Sustainability (IMaSS), Nagoya University.

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Author notes

  1. Yuriko Kiyokane

    Present address: Hitachi Metals Ltd., Hitachi, 319-1418, Japan

Authors and Affiliations

  1. Department of Materials Science & Biotechnology, Ehime University, Matsuyama, 790-8577, Japan

    Satoshi Okano & Sengo Kobayashi

  2. Department of Materials Science & Engineering, Ehime University, Matsuyama, 790-8577, Japan

    Yuriko Kiyokane

  3. Faculty of Education, Ehime University, Matsuyama, 790-8577, Japan

    Takeaki Okamoto

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Correspondence to Satoshi Okano.

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Okano, S., Kiyokane, Y., Kobayashi, S. et al. Effects of heat treatment of various pure metals on osteoblast cell activity. Journal of Materials Research 37, 2614–2622 (2022). https://doi.org/10.1557/s43578-022-00691-2

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  • DOI: https://doi.org/10.1557/s43578-022-00691-2

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