Skip to main content
SpringerLink
Log in

ATP aptamer/i-motif-grafted multi-functional SPION nanocarrier for chemotherapeutic/phototherapeutic synergistic research

  • Article
  • Published:
Journal of Materials Research Aims and scope Submit manuscript

Abstract

Poor tumor selectivity and high side toxicity have been frequently reported to hinder the application of chemotherapeutic agents. Thus, combining chemotherapeutic agents with other conventional cancer treatment modalities has attracted great attentions of pharmaceutical industries. Phototherapy has been intensively combined with chemotherapy to improve the biosafety and cytotoxicity. Herein, an ATP aptamer/i-motif-grafted multi-functional SPION nanocarrier (AGS) was constructed to co-deliver a chemotherapeutic agent DNM, and a photosensitizer TMPyP to the tumor tissues. The AGS sized around 60 nm was found well dispersed in water and the drug-loading efficiencies have been calculated to be 68.2% and 39.4% for DNM and TMPyP, respectively. The drug-loaded DDS displayed an ATP/pH dual-responsive drug release in vitro, which further exhibited significant cancer/normal cell selectivity, cellular internalization, high ROS production, cell-cycle arresting, and cell apoptosis against tumor cells. In vivo studies showed that the designed dual-drug DDS has satisfactory body safety and outstanding tumor suppression compared with individual and DNM-TMPyP-combined agents.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7

Similar content being viewed by others

Data availability

All data generated or analyzed during this study are included in this published article [and its supplementary information files].

References

  1. Z. Huang, L. Qiu, T. Zhang, W.H. Tan, Matter. 4, 461 (2021)

    Article  CAS  Google Scholar 

  2. H.L. Zhang, J. Wang, W. Zhang, D. Han, A.P. Zhang, Photochem. Photobiol. 97, 398 (2021)

    Article  CAS  Google Scholar 

  3. M. Ma, L. Cheng, A.Y. Zhao, H.L. Zhang, A.P. Zhang, Photodiagn. Photodyn. 29, 101640 (2020)

    Article  CAS  Google Scholar 

  4. H.Y. Shang, D. Han, M. Ma, S. Li, W.T. Xue, A.P. Zhang, J. Photoch. Photobio. B 177, 112 (2017)

    Article  CAS  Google Scholar 

  5. X.Y. Sun, P. Zhao, S.F. Jin, M.C. Liu, X.H. Wang, Y.M. Huang, Z.F. Cheng, S.Q. Yan, Y.Y. Li, Y.Q. Chen, Y.M. Zhong, J. Photochem. Photobiol. B 173, 606 (2017)

    Article  CAS  Google Scholar 

  6. P. Zhao, M. Liu, M. Zheng, S.F. Jin, D.T. Tang, J. Chen, Y.N. Ma, J.Q. Lin, X.H. Wang, H.J. Liu, Dyes Pigments 128, 41 (2016)

    Article  CAS  Google Scholar 

  7. S. Xie, L. Ai, C. Cui, T. Fu, X. Cheng, F. Qu, W.H. Tan, ACS Appl Mater. Interfaces 13, 9542 (2021)

    Article  CAS  Google Scholar 

  8. E. Campos-Fernandez, A.N. Oliveira, G. Moura, C. Lorrayne, Clin. Biochem. 93, 9 (2021)

    Article  CAS  Google Scholar 

  9. G. Ștefan, O. Hosu, K. Wael, M.J. Lobo-Castanon, C. Cristea, Electrochim. Acta. 376, 137994 (2021)

    Article  Google Scholar 

  10. F. Zhang, P.J. Huang, J. Liu, ACS Sensors 5, 2885 (2020)

    Article  CAS  Google Scholar 

  11. P. Srivastava, S.K. Hira, D.N. Srivastava, ACS Appl Mater Inter 10, 6917 (2018)

    Article  CAS  Google Scholar 

  12. X.Y. Sun, M.C. Liu, X.L. Chen, H.C. Lin, B. Liu, Y.B. Peng, L.Y. Zhang, J.L. Shen, P. Zhao, J. Lum. 209, 387 (2019)

    Article  CAS  Google Scholar 

  13. X.Y. Sun, B. Liu, X.L. Chen, H.C. Lin, Y.B. Peng, Y.Y. Li, H.R. Zheng, Y.B. Xu, X.L. Ou, S.Q. Yan, Z.H. Wu, S.J. Deng, L.Y. Zhang, P. Zhao, J. Mater. Sci-Mater. M. 30, 76 (2019)

    Article  Google Scholar 

  14. R. Gargallo, A. AviñóbR, P. Eritja, S. Jarosova, L. Mazzini, P.T. Scaglioni, Spectrochim. Acta. A 248, 119185 (2021)

    Article  CAS  Google Scholar 

  15. Y. Shieh, S.J. Yang, M.F. Wei, M.J. Shieh, ACS Nano 4, 1433 (2010)

    Article  CAS  Google Scholar 

  16. H.C. Lin, W.T. Li, W.M. Thushara, C. Tao, Q. Niu, S.Q. Yan, B.A. Gao, P. Zhao, J. Biomater. Appl. 34, 875 (2020)

    Article  CAS  Google Scholar 

  17. P. Školáková, Z. Badri, S. Trantírková, S. Foldynova-Trantirkova, J. Rynes, J. Sponer, M. Fojtova, J. Fajkus, R. Marek, M. Vorlickova, J.L. Mergny, L. Trantirek, BBA-Gen Subjects 1864, 129651 (2020)

    Article  Google Scholar 

  18. U. Mohan, T. Pichiah, P. Iqbal, S.T.A. Iqbal, S. Arunachalam, Reprod. Toxicol. 102, 80 (2021)

    Article  CAS  Google Scholar 

  19. P. Zhao, S.F. Jin, J. Lu, J.Z. Lu, J.L. Lv, G.Q. Wu, P.P. Chen, C.L. Tan, D.W. Chen, Spectrochim Acta A 137, 227 (2015)

    Article  CAS  Google Scholar 

  20. S. Jin, L. Xu, L.C. Xu, M. Zheng, J.Z. Lu, P.L. Zhao, Q.L. Su, H.X. Chen, D.T. Tang, J. Chen, J.Q. Lin, P. Zhao, Bioorg. Chem. 60, 110 (2015)

    Article  CAS  Google Scholar 

  21. M. Vázquez-González, I. Willner, A.C.S. Appl, Mater. Inter. 13, 9520 (2021)

    Article  Google Scholar 

  22. A. Krissanaprasit, C. Key, S. Pontula, T. LaBean, Self-assembling nucleic acid nanostructures functionalized with aptamers. Chem. Rev. (2021). https://doi.org/10.1021/acs.chemrev.0c01332

    Article  Google Scholar 

  23. M. Debnath, K. Fatma, J. Dash, Angew. Chem. Int. Edit. 58, 2942 (2019)

    Article  CAS  Google Scholar 

  24. S.L. Brown, S. Kendrick, Pharmaceuticals 14, 96 (2021)

    Article  CAS  Google Scholar 

  25. G. Sanita, B. Carrese, A. Lamberti, Front. Mol. Biosci. 7, 587012 (2020)

    Article  CAS  Google Scholar 

  26. L.I. FitzGerald, A. Johnston, J. Colloid. Interf. Sci. 587, 64 (2021)

    Article  CAS  Google Scholar 

  27. G. Maxime, D. Moataz, L. Ulo, Adv. Exp. Med. Boil. 1030, 255 (2017)

    Article  Google Scholar 

  28. J. Rehmat, C. Gul-e-Saba, Adv. Pharm. Bull. 9, 205 (2019)

    Article  Google Scholar 

  29. D. Arguello, A. Olivia, H. Hidde, Cancers 13, 1543 (2021)

    Article  CAS  Google Scholar 

  30. J. Moloney, T. Cotter, Semin. Cell Dev. Biol. 80, 50 (2018)

    Article  CAS  Google Scholar 

  31. I. Chio, D. Tuveson, Trends Mol. Med. 23, 411 (2017)

    Article  CAS  Google Scholar 

  32. A. Terasaki, H. Kurokawa, H.P. Indo, H. Bando, H. Hara, H.J. Majima, H. Matsui, H. Ito, J. Porphyr. Phthalocya. 23, 1440 (2019)

    Article  CAS  Google Scholar 

  33. P. Burk, Trends Cancer 3, 857 (2017)

    Article  Google Scholar 

Download references

Acknowledgments

This work has been supported in part by the National nature science foundation of China (21671150, 21877084), and the key scientific research projects of universities in Guangdong Province (2021ZDZX4019).

Author information

Authors and Affiliations

  1. College of Health Industry, Zhongshan Torch Polytechnic, No. 7 Xingye Road, Zhongshan, 528436, Guangdong, China

    Bo Fu & Nian Chen

  2. Zhongshan Functional Cosmetics (Zhongshan Torch Polytechnic) Engineering Technology Research Center, No. 7 Xingye Road, Zhongshan, 528436, Guangdong, China

    Bo Fu

  3. School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, No. 280, Waihuandong Road, Guangzhou, 510006, People’s Republic of China

    Hui-Chao Lin, Zi-Wei Tang & Ping Zhao

Authors
  1. Bo Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hui-Chao Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zi-Wei Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nian Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ping Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Bo Fu or Ping Zhao.

Ethics declarations

Conflict of interest

The authors declare that there are no conflict of interests, we do not have any possible conflicts of interest.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 778 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fu, B., Lin, HC., Tang, ZW. et al. ATP aptamer/i-motif-grafted multi-functional SPION nanocarrier for chemotherapeutic/phototherapeutic synergistic research. Journal of Materials Research 37, 2021–2032 (2022). https://doi.org/10.1557/s43578-022-00596-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1557/s43578-022-00596-0

Keywords

Search

Navigation