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Zinc curcumin complex on fluoride doped hydroxyapatite with enhanced biological properties for dental and orthopedic applications

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Abstract

Since antiquity, curcumin, from turmeric is utilized in traditional Indian medicine (Ayurveda) to treat bone disorders. However, the hydrophobic nature and poor absorption of curcumin limit its clinical applications. There is a need to develop a novel strategy that can significantly enhance curcumin’s biological properties. The current work reports the utilization of Zn2+–curcumin complex from a fluoride doped hydroxyapatite matrix for osteosarcoma inhibition, osteoblast growth, and anti-bacterial properties. The interaction between Zn2+ and curcumin increases curcumin release by ~ 2.5 folds. The fabricated drug delivery system shows up to ~ 1.6 times enhancement in osteoblast cell viability. The presence of curcumin results in ~ 4 times more osteosarcoma inhibition compared to control. The antibacterial efficacy of this system is confirmed against Staphylococcus aureus, due to the presence of antibacterial fluoride, zinc, and curcumin. This multifunctional drug delivery system can be utilized for various bone-tissue engineering and dental applications.

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Graphical abstract representing the summary of the current work from sample preparation to assessment of biological properties

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Data reported in this manuscript can be made available upon reasonable request.

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Acknowledgments

The authors acknowledge financial support from the National Institute of Dental and Craniofacial Research (NIDCR) of the NIH Grant Number R01 DE029204-01 (PI: Bose). The authors would also like to thank the Franceschi Microscopy & Imaging Center (Washington State University) and the Electron Microscopy Center (University of Idaho).

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Authors and Affiliations

  1. W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA

    Arjak Bhattacharjee & Susmita Bose

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  1. Arjak Bhattacharjee
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  2. Susmita Bose
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Correspondence to Susmita Bose.

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The authors do not have any possible conflict of interest. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Health.

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Susmita Bose was an editor of this journal during the review and decision stage. For the JMR policy on review and publication of manuscripts authored by editors, please refer to http://www.mrs.org/editor-manuscripts/

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Bhattacharjee, A., Bose, S. Zinc curcumin complex on fluoride doped hydroxyapatite with enhanced biological properties for dental and orthopedic applications. Journal of Materials Research 37, 2009–2020 (2022). https://doi.org/10.1557/s43578-022-00595-1

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