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Dental pulp stem cell viability and osteogenic potential assessment of new Mg-phosphate magnetic bioceramic nanoparticles

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Abstract

In this study, we introduced new magnetic nanoparticles based on iron oxide and Mg-phosphate ceramic (nMgP-Fe) for treatment of bone and pulp-dentin diseases. nMgP-Fe was characterized for the size, magnetism, and degradation properties, and its viability against human dental pulp-derived mesenchymal stem cells (DPSCs) was investigated as a first step to evaluate this material for dental pulp regeneration. The results showed that nMgP-Fe was characterized by its nanosize (10–40 nm), and the formed crystalline phases were farringonite and magnetite. Super-paramagnetic properties of nMgP-Fe were proved (coercivity and residual magnetization values were 20 Oe and 0.06 emu/g, respectively). The dissolution test demonstrated less release of iron ions than magnesium and phosphate ions. DPSCs incubated with nMgP-Fe particles showed a higher proliferation rate and increased osteogenic differentiation potentials compared to the control group. In conclusion, the new fabricated nanosized nMgP-Fe with its supramagnetic properties had biocompatible properties that make them a promising material for bone and pulp-dentin regeneration.

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Acknowledgments

The authors would like to thank the National Research Centre, Egypt, and the Oral Biology Department, Faculty of Dentistry, Cairo University, Egypt for the use of their facilities.

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Authors and Affiliations

  1. Glass Research Department, National Research Centre, 33 El Bohouth Str., Dokki, Giza, 12622, Egypt

    Mohammad M. Farag

  2. Department of Refractoriness, Ceramics and Building Materials, National Research Centre, 33 El Bohouth Str., Dokki, Giza, 12622, Egypt

    Hanan Beherei & Zainab M. Al-Rashidy

  3. Oral Biology Department, Faculty of Dentistry, Cairo University, Giza, Egypt

    Dina B. E. Farag & Zeinab A. Salem

  4. Oral Biology Department, Faculty of Oral and Dental Medicine, Ahram Canadian University, Giza, Egypt

    Zeinab A. Salem

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  1. Mohammad M. Farag
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Farag, M.M., Beherei, H., Al-Rashidy, Z.M. et al. Dental pulp stem cell viability and osteogenic potential assessment of new Mg-phosphate magnetic bioceramic nanoparticles. Journal of Materials Research 37, 595–607 (2022). https://doi.org/10.1557/s43578-021-00454-5

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