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Evaluation of amino acids capped silver nanoconjugates for the altered oxidative stress and antioxidant potential in albino mice

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Abstract

Recent data suggest that there is a continuous need to develop safer and less toxic nanomaterials (NMs). For this, the surface chemistry of commonly used NMs may be modified using several biomolecules/conjugates. The current study has been designed to develop silver nanoconjugates (AgNCs) capped with different amino acids. Characterization of the same was performed using different techniques. During in vitro analysis, l-tyrosine and l-cystine capped AgNCs exhibited antioxidant activity, while l-glycine capped AgNCs showed prooxidant activity. l-cystine and l-tyrosine capped AgNCs also demonstrated good in vivo results. The level of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and metallothioneins (MTs) in different organs was evaluated. It is assumed that newly developed nanoconjugates can be utilized as nano-tools for different applications. However, more detailed studies with resolution techniques for safety, the risk associated, and their accuracy are needed for the utilization of these nanoconjugates for specific biomedical uses.

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Acknowledgments

The authors acknowledge the Departments of Zoology and Chemistry, and the Centre for Advanced Studies in Physics (CASP), Government College University, Lahore, Pakistan, for their kind support in providing all the research facilities to undertake this study.

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  1. Department of Zoology, Government College University, Lahore, 54000, Pakistan

    Sarwar Allah Ditta, Atif Yaqub & Rehan Ullah

  2. Department of Zoology, University of Okara, Okara, 56300, Pakistan

    Fouzia Tanvir

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  1. Sarwar Allah Ditta
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Ditta, S.A., Yaqub, A., Ullah, R. et al. Evaluation of amino acids capped silver nanoconjugates for the altered oxidative stress and antioxidant potential in albino mice. Journal of Materials Research 36, 4344–4359 (2021). https://doi.org/10.1557/s43578-021-00427-8

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