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Multi-stimuli-responsive magnetic hydrogel based on Tragacanth gum as a de novo nanosystem for targeted chemo/hyperthermia treatment of cancer

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Abstract

A novel magnetic pH- and redox-responsive drug delivery system (DDS) based on natural Tragacanth gum (TG) was developed for targeted chemo/hyperthermia treatment of cancer. Firstly, acrylic acid (AA) monomer was grafted onto a maleic anhydride-functionalized TG macromonomer (MATGM) through a free radical copolymerization. Magnetic nanoparticles (MNPs) were synthesized through chemical co-precipitation, and subsequently were modified using (3-aminopropyl)triethoxysilane coupling agent. The magnetic stimuli-responsive hydrogel for targeted cancer therapy was synthesized by the incorporation of modified-MNPs and folic acid (FA), and simultaneous crosslinking of TG-g-PAA copolymer using cystamine (Cys) moiety. Doxorubicin hydrochloride (Dox) was loaded into the fabricated magnetic hydrogel (MH), and its release was studied under pH- and redox-triggered condition. The anti-cancer activity of the Dox-loaded DDS was examined against MCF7 cells through MTT assay by both chemotherapy and chemo/hyperthermia therapy approaches. It was revealed that the developed DDS has higher anti-cancer activity (~ 24%) owing to its “smart” and slow drug release behavior as well as synergic effect of hyperthermia therapy.

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A novel magnetite pH- and redox-responsive drug delivery system (DDS) based on natural Tragacanth gum (TG) was design and developed for targeted chemo/hyperthermia therapy of solid tumors.

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Acknowledgments

The authors gratefully acknowledge the Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran for funding assistance (Grant Number: 980958).

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Author notes

  1. These authors contributed equally as first authors.

Authors and Affiliations

  1. Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Rana Jahanban-Esfahlan

  2. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Khadijeh Soleimani, Aram Rezaei, Hadi Samadian & Mehdi Jaymand

  3. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Hossein Derakhshankhah

  4. Regenerative Medicine Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Babak Haghshenas

  5. Department of Chemistry, Payame Noor University, Tehran, Iran

    Bakhshali Massoumi

  6. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Amir Farnudiyan-Habibi

  7. Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Amir Farnudiyan-Habibi

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  1. Rana Jahanban-Esfahlan
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  9. Mehdi Jaymand
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Correspondence to Mehdi Jaymand.

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Jahanban-Esfahlan, R., Soleimani, K., Derakhshankhah, H. et al. Multi-stimuli-responsive magnetic hydrogel based on Tragacanth gum as a de novo nanosystem for targeted chemo/hyperthermia treatment of cancer. Journal of Materials Research 36, 858–869 (2021). https://doi.org/10.1557/s43578-021-00137-1

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  • DOI: https://doi.org/10.1557/s43578-021-00137-1

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