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Recent developments in implantable neural probe technologies

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Abstract

Understanding neural circuit functions requires tools that can interrogate the activity of a large number of neurons over extended periods of time. Implantable neural probes can record and modulate neuronal activities at high spatiotemporal resolution, representing one of the most applied tools in basic and applied neuroscience. Over the past decade, implantable neural probe technologies have evolved considerably in terms of capability and reliability. This article focuses on the latest developments in implantable neural probe technologies that are enabled by advanced materials and processing strategies. We highlight implantable neural probes that can allow for large-scale and long-lasting neural activity recordings. In addition, we describe recent developments in multifunctional neural probes for combined electrophysiological recording and modulation functionalities. The wide dissemination and clinical translation of these technologies will rapidly advance our understanding of the brain and provide new opportunities for the treatment of neurological diseases.

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Acknowledgments

This work is supported by the National Natural Science Foundation of China (Grant No. 32061143013), Major project of scientific and technological Innovation of 2030 (Grant Nos. 2021ZD0202200 and 2021ZD0202201).

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Authors and Affiliations

  1. CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China

    Hongyu Chen & Ying Fang

  2. CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China

    Ying Fang

  3. University of Chinese Academy of Sciences, Beijing, China

    Hongyu Chen & Ying Fang

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Chen, H., Fang, Y. Recent developments in implantable neural probe technologies. MRS Bulletin 48, 484–494 (2023). https://doi.org/10.1557/s43577-023-00535-2

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