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Dual Detection Platform with Refractive Index and SERS Sensing Based on Colloidal Gold Functionalized Porous Silicon Substrates

  • Materials And Sensors For Biomedical Applications
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Abstract

We demonstrate a dual-mode sensing platform based on porous silicon (PSi) substrates coated with colloidal gold (Au) nanoparticles (NPs). This Au-PSi composite structure supports both molecular fingerprinting via surface enhanced Raman scattering (SERS) and quantification of molecular binding via reflectance measurements. Reflectance shifts of 7–10 nm in the infrared region were observed in the case of adsorbing benzenethiol or antioxidant glutathione molecules on the surface of Au NPs. Subsequent SERS measurements showed unique identification for both molecules and provided a < 1 μM and < 1 mM detection resolution for benzenethiol and glutathione, respectively.

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Authors and Affiliations

  1. Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235, USA

    Yang Jiao & Sharon M. Weiss

  2. Department of Chemistry, Vanderbilt University, Nashville, TN, 37235, USA

    Dmitry S. Koktysh

  3. Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, TN, 37235, USA

    Dmitry S. Koktysh & Sharon M. Weiss

Authors
  1. Yang Jiao
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  2. Dmitry S. Koktysh
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  3. Sharon M. Weiss
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Correspondence to Sharon M. Weiss.

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Jiao, Y., Koktysh, D.S. & Weiss, S.M. Dual Detection Platform with Refractive Index and SERS Sensing Based on Colloidal Gold Functionalized Porous Silicon Substrates. MRS Online Proceedings Library 1301, 247–252 (2011). https://doi.org/10.1557/opl.2011.74

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  • DOI: https://doi.org/10.1557/opl.2011.74

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