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Study for the Interfacial Effect between a Crawling Cell and a Substrate on Chemotaxis

  • Multiscale Mechanics of Hierarchical Biological, Bioinspired, and Biomedical Materials
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Abstract

Chemotaxis is one of the essential mechanisms responsible for various complex biological processes. For a crawling cell, the interface between the cell and the substrate plays an important role in the chemotactic migration. This paper presents a three-dimensional dynamic model to investigate the effect of the interface between a crawling cell and a substrate on its chemotaxis. The coupled mechanisms of chemotaxis, the surface energy of the cell, and the interface between the cell and the substrate are incorporated into a diffuse interface model. Simulations reveal rich dynamics of a crawling cell associated with the interfacial condition, and confirm the high possibility of adequate predictions.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Sogang University, 1 Shinsoo-dong, Mapo-go, Seoul, Republic of Korea

    Jihwan Song & Dongchoul Kim

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  1. Jihwan Song
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  2. Dongchoul Kim
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Song, J., Kim, D. Study for the Interfacial Effect between a Crawling Cell and a Substrate on Chemotaxis. MRS Online Proceedings Library 1301, 199–203 (2011). https://doi.org/10.1557/opl.2011.473

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  • DOI: https://doi.org/10.1557/opl.2011.473

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