Abstract
Our work focuses on the earliest events of homo-/heterogeneous nucleation from an initial supersaturated solution to the subsequent growth of nuclei. The combined use of conductance, together with hydrogen and calcium ISEs has provided new insights into the mechanisms of crystal nucleation and phase stability. We propose that two types of ACP are formed during HAP nucleation. The initial subcritical calcium-phosphate ion clusters form an amorphous [CaHPO4·xH2O] phase (ACP-1), which transforms to amorphous [Ca3(PO4)2] (ACP-2), and subsequently to HAP. This study is a major step forward in our understanding of the earliest nucleation events in vitro and in vivo. Additives may influence HAP nucleation by interacting with ACP clusters during the early induction period.
Similar content being viewed by others
References
S. Weiner and H. D. Wagner, Annu. Rev. Mater. Sci. 28, 271–298 (1998).
S. I. Stupp and P. V. Braun, Science 277 (5330), 1242–1248 (1997).
J. R. Long, J. L. Dindot, H. Zebroski, S. Kiihne, R. H. Clark, A. A. Campbell, P. S. Stayton and G. P. Drobny, Proc. Natl. Acad. Sci. USA 95 (21), 12083–12087 (1998).
A. H. Heuer, D. J. Fink, V. J. Arias, P. D. Calvert, K. Kendali, G. L. Messing, J. Blackwell, P. Rieke, D. Thompson, A. P. Wheeler, A. Veis and A. I. Caplan, Science 255, 1098 (1992).
L. C. Palmer, C. J. Newcomb, S. R. Kaltz, E. D. Spoerke and S. I. Stupp, Chem. Rev. 108, 4754 (2008).
L. Wang and G. H. Nancollas, Chem. Rev. 108, 4628–4669 (2008).
Z. Wang, G. Ma and X. Y. Liu, J. Phys. Chem. B (113), 16393–16399 (2009).
X. Yang, L. Wang, Y. Qin, Z. Sun, Z. J. Henneman, J. Moradian-Oldak and G. H. Nancollas, J. Phys. Chem. B 114 (6), 2293–2300 (2010).
R. Tang, L. Wang and G. H. Nancollas, J. Mater. Chem. 14, 2341–2346 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Xie, B., Nancollas, G. Early Nucleation Events in the Biomineralization of Calcium Phosphates. MRS Online Proceedings Library 1301, 17–25 (2011). https://doi.org/10.1557/opl.2011.193
Published:
Issue Date:
DOI: https://doi.org/10.1557/opl.2011.193