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Effects of nanoporous Au on ATP synthase

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Abstract

Nanoporous Au shows the antimicrobial activity without the release of ROS. The cell wall is hyperpolarized by npAu. Hence, the hyperpolarized cell wall may affect ATP synthase, leading to the bacterial death. In the present work, the effects of the hyperpolarized cell wall on the structure and functions of Asp61 in ATP synthase are investigated by molecular dynamics simulations and first-principles calculations. The simulations suggest that the Asp61 is more negatively hyperpolarized, which is due to the strengthened O-H bond in Asp61, in interacting with the hyperpolarized cell wall, which results in the disturbance of proton transport in ATP synthase.

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Acknowledgment

N.M. acknowledges support from the Grant-in-Aid for JSPS Fellows.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, Nagatsuda-cho, Midori-ku, Yokohama, 226-8502, Japan

    Naoki Miyazawa

  2. Graduate School of Energy Science, Kyoto University, Yoshidahonmachi, Sakyo, Kyoto, 606-8501, Japan

    Masataka Hakamada & Mamoru Mabuchi

Authors
  1. Naoki Miyazawa
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  2. Masataka Hakamada
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  3. Mamoru Mabuchi
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Corresponding author

Correspondence to Naoki Miyazawa.

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The supplementary material for this article can be found at https://doi.org/10.1557/mrc.2020.8.

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Miyazawa, N., Hakamada, M. & Mabuchi, M. Effects of nanoporous Au on ATP synthase. MRS Communications 10, 173–178 (2020). https://doi.org/10.1557/mrc.2020.8

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