This work focuses on the functionalization of agave xylan-type hemicellulose functionalized with trimethoxysilylpropylmethacrylate and cross-linked with N-vinylcaprolactam to obtain a thermoresponsive material for potential applications in drug delivery. The hydrogels showed an interconnected and porous architecture with a lower critical solution temperature (LCST) close to poly(N-vinylcaprolactam)’s (PNVCL) LCST. These materials showed a good capacity to load ciprofloxacin (in the range 9.5 × 10−3-8.4 × 10−3 mg/mL), above the minimum inhibitory concentration (MIC = 0.004 × 10−3-0.5 × 10−3 mg/mL) for gram-positive and gram-negative bacteria. The hybrid hydrogel inhibited the growth of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.
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Authors thank the Instituto Transdisciplinar de Investigation y Servicios (ITRANS) of the Universidad de Guadalajara for technical assistance in NMR studies. Dr. L. Garcia-Uriostegui thanks CONACyT grant CB2016 (Project No. 283642) for financial support.
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Arellano-Sandoval, L., Delgado, E., Camacho-Villegas, T.A. et al. Development of thermosensitive hybrid hydrogels based on xylan-type hemicellulose from agave bagasse: characterization and antibacterial activity. MRS Communications 10, 147–154 (2020). https://doi.org/10.1557/mrc.2019.165