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Perfluorocarbon-based nanomedicine: emerging strategy for diagnosis and treatment of diseases

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Abstract

Nanotechnology has been considered as a promising strategy for diagnosis and treatment of various diseases. However, the stability and circulation times of the conventional nano-carriers, such as liposomes and micelles, are still unsatisfied. Perfluorocarbons (PFCs) are biologic inert synthetic materials, which are highly hydrophobic and have a tendency to self-aggregation. Additionally, PFCs themselves can act as 19F magnetic resonance imaging agents and oxygen carriers. Thus, the construction of the fluorinated carriers will not only improve the stability of the carriers, but also endow them with additional functions. Here we review the recent advances of PFC-based nanosystems for diagnosis and treatment of diseases.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (grant numbers 31771094 and 31371014). This work was also supported by the Natural Science Foundation key projects (grant numbers 31630027 and 31430031) and NSFC-DFG project (grant no. 31761133013). The authors also appreciate the support by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (grant no. XDA09030301).

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  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, People’s Republic of China

    Tingbin Zhang, Qian Zhang, Jian-Hua Tian & Jin-Feng Xing

  2. Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Centerfor Excellence in Nanoscience, National Centerfor Nanoscience and Technology of China, Beijing, 100190, People’s Republic of China

    Weisheng Guo & Xing-Jie Liang

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  1. Tingbin Zhang
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Correspondence to Jin-Feng Xing, Weisheng Guo or Xing-Jie Liang.

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Zhang, T., Zhang, Q., Tian, JH. et al. Perfluorocarbon-based nanomedicine: emerging strategy for diagnosis and treatment of diseases. MRS Communications 8, 303–313 (2018). https://doi.org/10.1557/mrc.2018.49

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